Abstract

EXCEED THE SPACE PROVIDED. University of Pittsburgh Pittsburgh, PA 15261 PERFORMANCE SITE(S) (organization, city, KEY PERSONNEL. See instructions on Page Start with Principal Investigator. List all other Name Duquesnoy, Rene, Ph.D. Brand, Anneke, M.D. Claas, Frans, Ph.D. Doxiadis, Ilias, Ph.D. Kiss, Joseph, M.D. Klein, Harvey, M.D. Lopez, Ileana, M.D. Marincola, Francesco, M.D. Mulder, Arend Ph.D. Tomson, Bert, M.D. Zeevi, Adriana, Ph.D. state) 11. Use continuation pages as needed to provide the key personnel in alphabetical order, last name first. required information in the format shown below. Organization University of Pittsburgh Medical Center Sanquin Blood Bank, The Netherlands Leiden University Medical Center Leiden University Medical Center Central Blood Bank, Pittsburgh Transfusion Medicine Clinical Center, NIH Central Blood Bank, Pittsburgh Transfusion Medicine Clinical Center, NIH Leiden University Medical Center Sanquin Blood Bank, The Netherlands University of Pittsburgh Medical Center Role Principal Investigator Consultant Consultant Consultant Co-Investigator Consultant Co-Investigator Consultant Consultant Consultant Co-Investigator on Project Disclosure Permission Statement. Applicable to SBIR/STTR Only. See instructions. [] Yes [] No PHS 398 (Rev. 5/01) Page 2 Number [age consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b. Form Page 2 ========================================Section End===========================================

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI055933-03
Application #
6836483
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Program Officer
Kirkham, Perry M
Project Start
2003-09-15
Project End
2007-12-31
Budget Start
2005-01-01
Budget End
2005-12-31
Support Year
3
Fiscal Year
2005
Total Cost
$318,382
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Pathology
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Marrari, Marilyn; Duquesnoy, Rene J (2010) Detection of donor-specific HLA antibodies before and after removal of a rejected kidney transplant. Transpl Immunol 22:105-9
Duquesnoy, R J; Marrari, M (2009) Correlations between Terasaki's HLA class I epitopes and HLAMatchmaker-defined eplets on HLA-A, -B and -C antigens. Tissue Antigens 74:117-33
Duquesnoy, Rene J; Marrari, Marilyn (2009) HLAMatchmaker-based definition of structural human leukocyte antigen epitopes detected by alloantibodies. Curr Opin Organ Transplant 14:403-9
Marrari, Marilyn; Duquesnoy, Rene J (2009) Why can sensitization by an HLA-DR2 mismatch lead to antibodies that react also with HLA-DR1? Hum Immunol 70:403-9
Marrari, M; Duquesnoy, R J (2009) Correlations between Terasaki's HLA class II epitopes and HLAMatchmaker-defined eplets on HLA-DR and -DQ antigens. Tissue Antigens 74:134-46
Duquesnoy, Rene J; Awadalla, Yehia; Lomago, Jon et al. (2008) Retransplant candidates have donor-specific antibodies that react with structurally defined HLA-DR,DQ,DP epitopes. Transpl Immunol 18:352-60
Duquesnoy, Rene; Spellman, Stephen; Haagenson, Michael et al. (2008) HLAMatchmaker-defined triplet matching is not associated with better survival rates of patients with class I HLA allele mismatched hematopoietic cell transplants from unrelated donors. Biol Blood Marrow Transplant 14:1064-71
Duquesnoy, Rene J; Mostecki, Justin; Hariharan, Jayasree et al. (2008) Structurally based epitope analysis of major histocompatibility complex class I-related chain A (MICA) antibody specificity patterns. Hum Immunol 69:826-32
Duquesnoy, Rene J (2008) Clinical usefulness of HLAMatchmaker in HLA epitope matching for organ transplantation. Curr Opin Immunol 20:594-601
Duquesnoy, Rene J (2008) Structural epitope matching for HLA-alloimmunized thrombocytopenic patients: a new strategy to provide more effective platelet transfusion support? Transfusion 48:221-7

Showing the most recent 10 out of 19 publications