Abstract

Multiple primate species, including 5 species of macaques (Macaca mulatta, M. nemestrina, M. fascicularis, M. assamensis, M. arctoides) and 3 species of langurs (Semnopithecus entellus, Trachypithecus phayrei, Trachypithecus pileatus) coexist with humans in different areas and ecological contexts (urban primates, temple primates, wildlife markets, pet primates, wild primates) in Bangladesh, one of the most densely populated countries in the world. This coexistence provides ample opportunity for human-primate interaction and poses a risk for cross-species transmission of infectious agents. Our proposed research will investigate the epizootiology, ecology and evolution of two simian retroviruses, simian foamy virus (SFV) and simian type D retrovirus (SRV) in macaques and langurs. We will also measure the prevalence of human infection with SFV and SRV among individuals exposed to macaques and langurs and describe how cross-species transmission may lead to viral recombination and evolution. All of these factors are important for the understanding of the potential emergence of new retroviral zoonotic disease(s).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI078229-05
Application #
8317717
Study Section
Special Emphasis Panel (ZRG1-GGG-J (02))
Program Officer
Park, Eun-Chung
Project Start
2008-08-01
Project End
2013-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
5
Fiscal Year
2012
Total Cost
$674,995
Indirect Cost
$69,004

  Institution

Name
University of Washington
Department
Type
Other Domestic Higher Education
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Eberle, R; Jones-Engel, L (2017) Understanding Primate Herpesviruses. J Emerg Dis Virol 3:
Klegarth, Amy R; Ezeonwu, Chigozie A; Rompis, Aida et al. (2017) Survey of Treponemal Infections in Free-Ranging and Captive Macaques, 1999-2012. Emerg Infect Dis 23:816-819
Hasan, M Kamrul; Feeroz, M Mostafa; Jones-Engel, Lisa et al. (2016) Performing monkeys of Bangladesh: characterizing their source and genetic variation. Primates 57:221-30
Karlsson, Erik A; Small, Christopher T; Freiden, Pamela et al. (2015) Non-Human Primates Harbor Diverse Mammalian and Avian Astroviruses Including Those Associated with Human Infections. PLoS Pathog 11:e1005225
Rosenbaum, Marieke; Mendoza, Patricia; Ghersi, Bruno M et al. (2015) Detection of Mycobacterium tuberculosis Complex in New World Monkeys in Peru. Ecohealth 12:288-97
Craig, Karen L; Hasan, M Kamrul; Jackson, Dana L et al. (2015) A Seminomadic Population in Bangladesh with Extensive Exposure to Macaques Does Not Exhibit High Levels of Zoonotic Simian Foamy Virus Infection. J Virol 89:7414-6
Stenbak, Carolyn R; Craig, Karen L; Ivanov, Sergei B et al. (2014) New World simian foamy virus infections in vivo and in vitro. J Virol 88:982-91
Matsen 4th, Frederick A; Small, Christopher T; Soliven, Khanh et al. (2014) A novel Bayesian method for detection of APOBEC3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses. PLoS Comput Biol 10:e1003493
Hasan, M Kamrul; Feeroz, M Mostafa; Jones-Engel, Lisa et al. (2014) Diversity and molecular phylogeny of mitochondrial DNA of rhesus macaques (Macaca mulatta) in Bangladesh. Am J Primatol 76:1094-104
Engel, Gregory A; Fuentes, Agustin; Lee, Benjamin P Y-H et al. (2013) Monkey bites among U.S. military members, Afghanistan, 2011. Emerg Infect Dis 19:691

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