Reactivation in B-cells is critical for the Epstein Barr virus (EBV) life cycle and it plays a role in amplifying viral titers in AIDS patients. The repertoire of EBV genes thought to be involved in viral replication consists primarily of approximately 80-90 protein-coding genes. These viral proteins play very diverse roles in virus production including roles in DNA replication, RNA transcription, molecular trafficking, virion assembly, viral egress, host shut-off etc. This is not to mention roles as viron components;both components that form the virus architecture as well as those that are involved in inducing the rapid signaling responses immediately following new infection. We hypothesize that in addition to this group of known protein coding genes, EBV encodes a previously unappreciated group of long non-coding transcripts that will ultimately be found to play an equally diverse set of functions in virus replication. Conceptually this would be important because it would change the texture and the details of how most of us visualize the reactivation process. From a practical standpoint, it would give us a new class of molecular targets that may offer the application of alternative therapeutic approaches against EBV.
The replication phase of the Epstein Barr virus results in the production of infectious virions and the spread of the virus within the host. In AIDS patients, virl proteins produced during the replication phase as well as oncogenic latency proteins are not as well targeted by the immune system, resulting in additional pathogenic consequences including lymphomas. Here we propose a new regulatory model for how EBV facilitates progression through the viral replication phase.
|Bullard, Whitney L; Flemington, Erik K; Renne, Rolf et al. (2018) Connivance, Complicity, or Collusion? The Role of Noncoding RNAs in Promoting Gammaherpesvirus Tumorigenesis. Trends Cancer 4:729-740|
|Dai, Lu; Del Valle, Luis; Miley, Wendell et al. (2018) Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi's sarcoma development. Oncogene 37:4534-4545|
|Lin, Zhen; Nguyen, Christian; Xu, Beibei et al. (2018) Interleukin-17A in the Pathogenesis of Lung Adenocarcinoma. Ann Am Thorac Soc 15:S125|
|Ungerleider, Nathan; Concha, Monica; Lin, Zhen et al. (2018) The Epstein Barr virus circRNAome. PLoS Pathog 14:e1007206|
|Schouest, Blake; Weiler, Andrea M; Janaka, Sanath Kumar et al. (2018) Maintenance of AP-2-Dependent Functional Activities of Nef Restricts Pathways of Immune Escape from CD8 T Lymphocyte Responses. J Virol 92:|
|Zhang, Wensheng; Flemington, Erik K; Deng, Hong-Wen et al. (2018) Epigenetically silenced candidate tumor suppressor genes in prostate cancer: identified by modelling methylation stratification and applied to progression prediction. Cancer Epidemiol Biomarkers Prev :|
|Dai, Lu; Lin, Zhen; Jiang, Wei et al. (2017) Lipids, lipid metabolism and Kaposi's sarcoma-associated herpesvirus pathogenesis. Virol Sin 32:369-375|
|Penrose, Harrison M; Heller, Sandra; Cable, Chloe et al. (2017) High-fat diet induced leptin and Wnt expression: RNA-sequencing and pathway analysis of mouse colonic tissue and tumors. Carcinogenesis 38:302-311|
|Li, Miao; Li, Xi; Zhuang, Yan et al. (2017) Induction of a novel isoform of the lncRNA HOTAIR in Claudin-low breast cancer cells attached to extracellular matrix. Mol Oncol 11:1698-1710|
|Heller, Sandra; Penrose, Harrison M; Cable, Chloe et al. (2017) Reduced mitochondrial activity in colonocytes facilitates AMPK?2-dependent inflammation. FASEB J 31:2013-2025|
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