This application focuses on development of efficacious universal influenza vaccine. Specifically, we will capitalize on the innovative attributes of our new Ad5 [E1-, E2b-] recombinant platform and develop a broadly cross-reactive flu vaccine. This will be accomplished by incorporating into our recombinant Ad5 [E1-, E2b-] platform fused transgenes that will express conserved and cross-reactive antigens from the HA, BM2, M2 and NP proteins of influenza A and B strains to be utilized as a new vaccine. The vaccine will be tested in mice and ferrets for its efficacy against various influenza A and B viruses, including highly pathogenic avian H5N1 viruses. In the last years we will perform toxicology and biodistribution studies under GLP and finalize the vaccine stability studies in order to prepare an IND application with the FDA.

Public Health Relevance

This study will develop and produce a recombinant vaccine against various influenza A and B viruses, a so-called universal flu vaccine. Additionally, we will generate data concerning its safety and stability and will test its immunogenicity and efficacy in two animal models. We propose a novel system for vaccine production against epidemic and potentially pandemic influenza viruses in order to increase our ability to prevent some of the most severe infectious diseases in the USA and worldwide.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI111364-02
Application #
8836966
Study Section
Special Emphasis Panel (ZAI1-JRR-M (J4))
Program Officer
Salomon, Rachelle
Project Start
2014-04-10
Project End
2019-03-31
Budget Start
2015-04-01
Budget End
2016-03-31
Support Year
2
Fiscal Year
2015
Total Cost
$1,121,460
Indirect Cost
$334,190
Name
Etubics Corporation
Department
Type
DUNS #
154453018
City
Seattle
State
WA
Country
United States
Zip Code
98119