Abstract

This investigation aims to explore the metabolism of ursodeoxycholic acid in human subjects with gallstones treated either with ursodeoxycholic acid or chenodeoxycholic acid. Specifically, we will conduct a clinical trial to determine if ursodeoxycholic acid is a superior litholytic (gallstone dissolving) agent than chenodeoxycholic acid and if fewer side effects are noted during treatment with ursodeoxycholic acid. Other parameters that will be measured during this trial include (a) pool size and daily production rate by isotope dilution techniques (b) effect on hepatic microsomal HMG CoA reductase and cholesterol 7 alpha-hydroxylase activity (c) difference in the bacterial metabolism of the 7 alpha and 7 beta hydroxyl groups of chenodeoxycholic acid and ursodeoxycholic acid (d) effect on intestinal cholesterol absorption (e) pathway and tissue site of formation of ursodeoxycholic acid.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases (NIADDK)
Type
Research Project (R01)
Project #
5R01AM018707-10
Application #
3151156
Study Section
(GCN)
Project Start
1977-07-01
Project End
1987-03-31
Budget Start
1985-04-01
Budget End
1987-03-31
Support Year
10
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Medicine & Dentistry of NJ
Department
Type
Schools of Medicine
DUNS #
605799469
City
Newark
State
NJ
Country
United States
Zip Code

  Publications

Dayal, B; Salen, G; Dayal, V (1991) The use of microwave oven for the rapid hydrolysis of bile acid methyl esters. Chem Phys Lipids 59:97-103
Dayal, B; Salen, G (1991) Stereospecific synthesis and two-dimensional 1H-NMR investigation of isoursocholic acid. J Lipid Res 32:1381-7
Batta, A K; Salen, G; Shefer, S (1989) Characterization of sarcosylsarcoursodeoxycholic acid formed during the synthesis of sarcoursodeoxycholic acid. J Lipid Res 30:771-4
Batta, A K; Salen, G; Arora, R et al. (1989) Effect of ursodeoxycholic acid on bile acid metabolism in primary biliary cirrhosis. Hepatology 10:414-9
Batta, A K; Salen, G; Shefer, S (1988) Chromatographic separation of putative precursors of cholestanol. Steroids 52:109-22
Batta, A K; Salen, G; Shefer, S et al. (1987) Increased plasma bile alcohol glucuronides in patients with cerebrotendinous xanthomatosis: effect of chenodeoxycholic acid. J Lipid Res 28:1006-12
Salen, G; Berginer, V; Shore, V et al. (1987) Increased concentrations of cholestanol and apolipoprotein B in the cerebrospinal fluid of patients with cerebrotendinous xanthomatosis. Effect of chenodeoxycholic acid. N Engl J Med 316:1233-8
Tint, G S; Bullock, J; Batta, A K et al. (1986) Ursodeoxycholic acid, 7-ketolithocholic acid, and chenodeoxycholic acid are primary bile acids of the nutria (Myocastor coypus). Gastroenterology 90:702-9
Tint, G S; Salen, G; Shefer, S (1986) Effect of ursodeoxycholic acid and chenodeoxycholic acid on cholesterol and bile acid metabolism. Gastroenterology 91:1007-18
Dayal, B; Salen, G; Toome, V et al. (1986) Configuration at C-25 in 5 beta-cholestane-3 alpha,7 alpha,12 alpha,25,26-pentol excreted by patients with cerebrotendinous xanthomatosis: circular dichroism and 13C-NMR studies. J Lipid Res 27:1328-32

Showing the most recent 10 out of 16 publications