The long-term objective of this renewal proposal is to produce accelerated growth of the growth plate in Beagle puppies with capacitively coupled electricity.
The specific aims are 1) to determine if an appropriate capacitively coupled electrical signal can produce significant, prolonged acceleration of the puppy radius as measured with three-dimensional biplanar roentgenography utilizing tantalum epiphyseal and diaphyseal markers, and 2) to determine the effect of the applied electrical field on growth plate closure, be it premature closure, delayed closure, or normal time of closure. Successful prolonged acceleration of the puppy radius will set the stage for the translation of this data to clinical application in the child with limb length inequality.
| Conzemius, M G; Smith, G K; Brighton, C T et al. (1994) Analysis of physeal growth in dogs, using biplanar radiography. Am J Vet Res 55:22-7 |
| Clark, C C; Tolin, B S; Brighton, C T (1991) The effect of oxygen tension on proteoglycan synthesis and aggregation in mammalian growth plate chondrocytes. J Orthop Res 9:477-84 |
| Iannotti, J P; Brighton, C T; Stambough, J E (1989) Subcellular regulation of the ionized calcium pool in isolated growth-plate chondrocytes. Clin Orthop Relat Res :285-93 |
| Iannotti, J P; Brighton, C T (1989) Cytosolic ionized calcium concentration in isolated chondrocytes from each zone of the growth plate. J Orthop Res 7:511-8 |
