Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
1R01AR039020-01
Application #
3159058
Study Section
Biochemistry Study Section (BIO)
Project Start
1988-04-01
Project End
1988-08-31
Budget Start
1988-04-01
Budget End
1988-08-31
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Thomas, T J; Gunnia, U B; Seibold, J R et al. (1995) Defective signal-transduction pathways in T-cells from autoimmune MRL-lpr/lpr mice are associated with increased polyamine concentrations. Biochem J 311 ( Pt 1):175-82
Faaland, C A; Laskin, J D; Thomas, T J (1995) Inhibition of epidermal growth factor-stimulated EGF receptor tyrosine kinase activity in A431 human epidermoid carcinoma cells by polyamines. Cell Growth Differ 6:115-21
Hsu, H C; Seibold, J R; Thomas, T J (1994) Regulation of ornithine decarboxylase in the kidney of autoimmune mice with the lpr gene. Autoimmunity 19:253-64
Thomas, T; Thomas, T J (1993) Structural specificity of polyamines in modulating the binding of estrogen receptor to potential Z-DNA forming sequences. J Recept Res 13:1115-33
Hsu, H C; Thomas, T; Seibold, J R et al. (1993) Studies on the effects of an ornithine decarboxylase inhibitor on lupus nephritis reveal a post-transcriptional modification of the enzyme. Agents Actions 39 Spec No:C204-6
Adams, L E; Balakrishnan, K; Roberts, S M et al. (1993) Genetic, immunologic and biotransformation studies of patients on procainamide. Lupus 2:89-98
Thomas, T J; Seibold, J R; Adams, L E et al. (1993) Hydralazine induces Z-DNA conformation in a polynucleotide and elicits anti(Z-DNA) antibodies in treated patients. Biochem J 294 ( Pt 2):419-25
Singh, A B; Thomas, T J; Singh, M et al. (1992) Attenuation of murine acute lethal graft-versus-host disease by the administration of DL-alpha-difluoromethylornithine. Clin Immunol Immunopathol 65:242-6
Thomas, T J; Gunnia, U B; Thomas, T (1992) Reversal of the abnormal development of T cell subpopulations in the thymus of autoimmune MRL-lpr/lpr mice by a polyamine biosynthesis inhibitor. Autoimmunity 13:275-83
Mongey, A B; Donovan-Brand, R; Thomas, T J et al. (1992) Serologic evaluation of patients receiving procainamide. Arthritis Rheum 35:219-23

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