Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
2R01AR039472-06A3
Application #
2079538
Study Section
Biochemistry Study Section (BIO)
Project Start
1989-03-01
Project End
2000-11-30
Budget Start
1996-03-01
Budget End
1996-11-30
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Saffarian, Saveez; Collier, Ivan E; Marmer, Barry L et al. (2004) Interstitial collagenase is a Brownian ratchet driven by proteolysis of collagen. Science 306:108-11
Bannikov, Gregory A; Karelina, Tatiana V; Collier, Ivan E et al. (2002) Substrate binding of gelatinase B induces its enzymatic activity in the presence of intact propeptide. J Biol Chem 277:16022-7
Collier, I E; Saffarian, S; Marmer, B L et al. (2001) Substrate recognition by gelatinase A: the C-terminal domain facilitates surface diffusion. Biophys J 81:2370-7
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Karelina, T V; Hruza, G J; Goldberg, G I et al. (1993) Localization of 92-kDa type IV collagenase in human skin tumors: comparison with normal human fetal and adult skin. J Invest Dermatol 100:159-65
Strongin, A Y; Marmer, B L; Grant, G A et al. (1993) Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP-2. J Biol Chem 268:14033-9
Strongin, A Y; Collier, I E; Krasnov, P A et al. (1993) Human 92 kDa type IV collagenase: functional analysis of fibronectin and carboxyl-end domains. Kidney Int 43:158-62
Hasty, K A; Wu, H; Byrne, M et al. (1993) Susceptibility of type I collagen containing mutated alpha 1(1) chains to cleavage by human neutrophil collagenase. Matrix 13:181-6

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