Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR042533-03
Application #
2081865
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
1993-12-10
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Albert Einstein College of Medicine
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461

  Publications

Kalergis, A M; Boucheron, N; Doucey, M A et al. (2001) Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex. Nat Immunol 2:229-34
Thomson, C T; Kalergis, A M; Sacchettini, J C et al. (2001) A structural difference limited to one residue of the antigenic peptide can profoundly alter the biological outcome of the TCR-peptide/MHC class I interaction. J Immunol 166:3994-7
Kalergis, A M; Nathenson, S G (2000) Altered peptide ligand-mediated TCR antagonism can be modulated by a change in a single amino acid residue within the CDR3 beta of an MHC class I-restricted TCR. J Immunol 165:280-5
Kuo, P; Bynoe, M S; Wang, C et al. (1999) Bcl-2 leads to expression of anti-DNA B cells but no nephritis: a model for a clinical subset. Eur J Immunol 29:3168-78
Kalergis, A M; Ono, T; Wang, F et al. (1999) Single amino acid replacements in an antigenic peptide are sufficient to alter the TCR V beta repertoire of the responding CD8+ cytotoxic lymphocyte population. J Immunol 162:7263-70
Wang, F; Ono, T; Kalergis, A M et al. (1998) On defining the rules for interactions between the T cell receptor and its ligand: a critical role for a specific amino acid residue of the T cell receptor beta chain. Proc Natl Acad Sci U S A 95:5217-22
Ono, T; DiLorenzo, T P; Wang, F et al. (1998) Alterations in TCR-MHC contacts subsequent to cross-recognition of class I MHC and singly substituted peptide variants. J Immunol 161:5454-63
Spatz, L; Saenko, V; Iliev, A et al. (1997) Light chain usage in anti-double-stranded DNA B cell subsets: role in cell fate determination. J Exp Med 185:1317-26