Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
1R01AR043769-01A1
Application #
2083519
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Project Start
1996-09-27
Project End
2000-08-31
Budget Start
1996-09-27
Budget End
1997-08-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Orthopedics
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Islam, Andrew S; Beidelschies, Michelle A; Huml, Anne et al. (2011) Titanium particles activate toll-like receptor 4 independently of lipid rafts in RAW264.7 murine macrophages. J Orthop Res 29:211-7
Beidelschies, Michelle A; Huang, Honglian; McMullen, Megan R et al. (2008) Stimulation of macrophage TNFalpha production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NF-kappaB pathways but is independent of p38 and JNK. J Cell Physiol 217:652-66
Smith, Matthew V; Lee, Michael J; Islam, Andrew S et al. (2007) Inhibition of the PI3K-Akt signaling pathway reduces tumor necrosis factor-alpha production in response to titanium particles in vitro. J Bone Joint Surg Am 89:1019-27
Taki, Naoya; Tatro, Joscelyn M; Lowe, Robert et al. (2007) Comparison of the roles of IL-1, IL-6, and TNFalpha in cell culture and murine models of aseptic loosening. Bone 40:1276-83
Tatro, Joscelyn M; Taki, Naoya; Islam, Andrew S et al. (2007) The balance between endotoxin accumulation and clearance during particle-induced osteolysis in murine calvaria. J Orthop Res 25:361-9
Taki, Naoya; Tatro, Joscelyn M; Nalepka, Jennifer L et al. (2005) Polyethylene and titanium particles induce osteolysis by similar, lymphocyte-independent, mechanisms. J Orthop Res 23:376-83
Greenfield, Edward M; Bi, Yanming; Ragab, Ashraf A et al. (2005) Does endotoxin contribute to aseptic loosening of orthopedic implants? J Biomed Mater Res B Appl Biomater 72:179-85
Nalepka, Jennifer L; Greenfield, Edward M (2004) Detection of bacterial endotoxin in human tissues. Biotechniques 37:413-7
Ragab, Ashraf A; Nalepka, Jennifer L; Bi, Yanming et al. (2002) Cytokines synergistically induce osteoclast differentiation: support by immortalized or normal calvarial cells. Am J Physiol Cell Physiol 283:C679-87
Greenfield, Edward M; Bi, Yamming; Ragab, Ashraf A et al. (2002) The role of osteoclast differentiation in aseptic loosening. J Orthop Res 20:1-8

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