Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR044130-11
Application #
2083853
Study Section
Special Emphasis Panel (ZRG4-GMA-2 (01))
Project Start
1985-09-30
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Schepens Eye Research Institute
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02114
Niizeki, Hironori; Inoko, Hidetoshi; Wayne Streilein, J (2002) Polymorphisms in the TNF region confer susceptibility to UVB-induced impairment of contact hypersensitivity induction in mice and humans. Methods 28:46-54
Alard, P; Kurimoto, I; Niizeki, H et al. (2001) Hapten-specific tolerance induced by acute, low-dose ultraviolet B radiation of skin requires mast cell degranulation. Eur J Immunol 31:1736-46
Niizeki, H; Naruse, T; Hecker, K H et al. (2001) Polymorphisms in the tumor necrosis factor (TNF) genes are associated with susceptibility to effects of ultraviolet-B radiation on induction of contact hypersensitivity. Tissue Antigens 58:369-78
Kitazawa, T; Streilein, J W (2000) Hapten-specific tolerance promoted by calcitonin gene-related peptide. J Invest Dermatol 115:942-8
Kurimoto, I; Kitazawa, T; Streilein, J W (2000) Suprathreshold doses of hapten are required to induce both contact hypersensitivity and tolerance. J Dermatol Sci 24:48-59
Kitazawa, T; Streilein, J W (2000) Studies on delayed systemic effects of ultraviolet B radiation on the induction of contact hypersensitivity, 3. Dendritic cells from secondary lymphoid organs are deficient in interleukin-12 production and capacity to promote activation and differentiatio Immunology 99:296-304
Kurimoto, I; Kitazawa, T; Streilein, J W (2000) Studies of delayed systemic effects of ultraviolet B radiation (UVR) on the induction of contact hypersensitivity, 2. Evidence that interleukin-10 from UVR-treated epidermis is the critical mediator. Immunology 99:134-40
Xie, Y; Li, Y; Zhang, Q et al. (2000) Haptoglobin is a natural regulator of Langerhans cell function in the skin. J Dermatol Sci 24:25-37
Zhu, S N; Yamada, J; Streilein, J W et al. (2000) ICAM-1 deficiency suppresses host allosensitization and rejection of MHC-disparate corneal transplants. Transplantation 69:1008-13
Nakamura, T; Kurimoto, I; Itami, S et al. (2000) Genetic factors in immunosuppression: precise genetic evidence that polymorphism of TNF-alpha dictates UVB-susceptibility in mice. J Dermatol Sci 23 Suppl 1:S13-6

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