Description): The focus of this research will be on the determination of the risk factors for bone fragility fractures in growing individuals by using a case-control method. The research will permit: 1)the determination of bone mineral density of the forearm, spine, hip, and of the whole skeleton in children and adolescents with distal forearm fracture as well as in normal controls; and 2) the determination of dietary calcium intakes in cases and control. The hypothesis is that children with distal forearm fracture due to moderate trauma have substantially lower bone mineral density at the forearm and other skeletal regions of interest, and lower dietary calcium intakes. This data base will be a major resource for the determination of risk factors for bone fragility fractures during growth. In addition, this research will provide significant believable evidence that calcium may immediately reduce the number of fractures in children. This will be a powerful incentive to maintain healthy nutritional habits with regard to research data important for the design of a large scale intervention study with calcium n young Americans, looking for the reduction in the fracture incidence as the primary outcome variable.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR045547-04
Application #
6375153
Study Section
Special Emphasis Panel (ZHD1-RRG-K (06))
Program Officer
Mcgowan, Joan A
Project Start
1998-07-01
Project End
2003-06-30
Budget Start
2001-07-01
Budget End
2003-06-30
Support Year
4
Fiscal Year
2001
Total Cost
$268,227
Indirect Cost
Name
Ohio State University
Department
Physical Medicine & Rehab
Type
Schools of Medicine
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210