The overall objective of this grant is to provide information and equipment that will facilitate the use of hyperthermia as a clinical tool.
The specific aims for the 1985-1989 period are: 1. To determine the response of tumors to drug and heat as a function of pH. 2. To determine mechanisms for the increased interaction between many drugs and heat at low pH. 3. To determine the influence of thermotolerance on drug-heat interactions and to see if heat-drug cross resistance can be used as an assay for drug response. 4. To determine if ultrasound has effects on heat-drug interactions over and above those from heat alone. Drugs: Adriamycin, bleomycin, BCNU, cis-platinum Experimental techniques include: tissue culture, transplantable mouse tumors (RIF, EMT-6, B-16 melanoma), FACS, gel electrophoresis, fluorescent dyes, ultrasound and radiofrequency heating

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA019386-16
Application #
3165149
Study Section
Radiation Study Section (RAD)
Project Start
1976-12-01
Project End
1995-02-28
Budget Start
1992-03-01
Budget End
1993-02-28
Support Year
16
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Stanford University
Department
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
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Saad, A H; Hahn, G M (1989) Ultrasound enhanced drug toxicity on Chinese hamster ovary cells in vitro. Cancer Res 49:5931-4

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