Abstract

The overall objective of this grant is to provide information and equipment that will facilitate the use of hyperthermia as a clinical tool.
The specific aims for the 1985-1989 period are: 1. To determine the response of tumors to drug and heat as a function of pH. 2. To determine mechanisms for the increased interaction between many drugs and heat at low pH. 3. To determine the influence of thermotolerance on drug-heat interactions and to see if heat-drug cross resistance can be used as an assay for drug response. 4. To determine if ultrasound has effects on heat-drug interactions over and above those from heat alone. Drugs: Adriamycin, bleomycin, BCNU, cis-platinum Experimental techniques include: tissue culture, transplantable mouse tumors (RIF, EMT-6, B-16 melanoma), FACS, gel electrophoresis, fluorescent dyes, ultrasound and radiofrequency heating

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA019386-18
Application #
2086767
Study Section
Radiation Study Section (RAD)
Project Start
1976-12-01
Project End
1995-02-28
Budget Start
1994-03-01
Budget End
1995-02-28
Support Year
18
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Park, Y M; Mivechi, N F; Auger, E A et al. (1994) Altered regulation of heat shock gene expression in heat resistant mouse cells. Int J Radiat Oncol Biol Phys 28:179-87
Tata, D B; Hahn, G; Dunn, F (1993) Ultrasonic absorption frequency dependence of two widely used anti-cancer drugs: doxorubicin and daunorubicin. Ultrasonics 31:447-50
Park, Y M; Anderson, R L; Spitz, D R et al. (1992) Hypoxia and resistance to hydrogen peroxide confer resistance to tumor necrosis factor in murine L929 cells. Radiat Res 131:162-8
Hahn, G M; Shiu, E C; Auger, E A (1991) Mammalian stress proteins HSP70 and HSP28 coinduced by nicotine and either ethanol or heat. Mol Cell Biol 11:6034-40
Hiraoka, M; Hahn, G M (1990) Changes in pH and blood flow induced by glucose, and their effects on hyperthermia with or without BCNU in RIF-1 tumours. Int J Hyperthermia 6:97-103
Goffinet, D R; Prionas, S D; Kapp, D S et al. (1990) Interstitial 192Ir flexible catheter radiofrequency hyperthermia treatments of head and neck and recurrent pelvic carcinomas. Int J Radiat Oncol Biol Phys 18:199-210
Srinivasan, J M; Fajardo, L F; Hahn, G M (1990) Mechanism of antitumor activity of tumor necrosis factor alpha with hyperthermia in a tumor necrosis factor alpha-resistant tumor. J Natl Cancer Inst 82:1904-10
Gonzalez-Mendez, R R; Hahn, G M (1989) Effects of hyperthermia on the intracellular pH and membrane potential of Chinese hamster ovary cells. Int J Hyperthermia 5:69-84
Hahn, G M; Ning, S C; Elizaga, M et al. (1989) A comparison of thermal responses of human and rodent cells. Int J Radiat Biol 56:817-25
Saad, A H; Hahn, G M (1989) Ultrasound enhanced drug toxicity on Chinese hamster ovary cells in vitro. Cancer Res 49:5931-4

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