We propose to continue research directed toward the development and use of the intramolecular 1,3-diyl trapping reaction in organic synthesis. The proposal describes what one might refer to as a """"""""second generation"""""""" of the diyl trapping reaction, one which leads to the formation of products other than the linearly fused tricyclopentanoid ring system. Specifically, we intend to focus attention upon the synthesis of the trichothecane antitumor agents trichodermol and verrucarol, the diterpene aphidicolin, as well as the tigliane natural products exemplified by the interesting tumor promotors, the phorbol esters.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA021144-11
Application #
3165474
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1980-12-01
Project End
1989-11-30
Budget Start
1987-12-01
Budget End
1988-11-30
Support Year
11
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of California Santa Barbara
Department
Type
Schools of Arts and Sciences
DUNS #
City
Santa Barbara
State
CA
Country
United States
Zip Code
93106