Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA025078-08S2
Application #
3166680
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1981-08-01
Project End
1987-03-31
Budget Start
1985-07-01
Budget End
1987-03-31
Support Year
8
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
Ghoshal, K; Jacob, S T (1991) Ara-ATP impairs 3'-end processing of pre-mRNAs by inhibiting both cleavage and polyadenylation. Nucleic Acids Res 19:5871-5
Chrislip, K M; Hengst-Zhang, J A; Jacob, S T (1991) Polyadenylation of SV40 late pre-mRNA is dependent on phosphorylation of an essential component associated with the 3' end processing machinery. Gene Expr 1:197-206
Jacob, S T; Zhang, J; Garg, L C et al. (1991) Multiple functional enhancer motifs of rat ribosomal gene. Mol Cell Biochem 104:155-62
Raju, V S; Jacob, S T (1991) Anti-poly(A) polymerase antibodies in the sera of tumor-bearing rats can inhibit specific cleavage and polyadenylation reactions. Carcinogenesis 12:917-20
Hengst-Zhang, J A; Jacob, S T (1990) Tissue and species distribution of liver type and tumor type nuclear poly(A) polymerases. Biochem Biophys Res Commun 169:325-31
Jacob, S T; Terns, M P; Hengst-Zhang, J A et al. (1990) Polyadenylation of mRNA and its control. Crit Rev Eukaryot Gene Expr 1:49-59
Garg, L C; Dixit, A; Jacob, S T (1989) A 37-base pair element in the far upstream spacer region can enhance transcription of rat rDNA in vitro and can bind to the core promoter-binding factor(s). J Biol Chem 264:220-4
Garg, L C; Dixit, A; Webb, M L et al. (1989) Interaction of a positive regulatory factor(s) with a 106-base pair upstream region controls transcription of metallothionein-I gene in the liver. J Biol Chem 264:2134-8
Terns, M P; Jacob, S T (1989) Role of poly(A) polymerase in the cleavage and polyadenylation of mRNA precursor. Mol Cell Biol 9:1435-44
Jacob, S T; Terns, M P; Maguire, K A (1989) Polyadenylate polymerases from normal and cancer cells and their potential role in messenger RNA processing: a review. Cancer Res 49:2827-33

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