Abstract

The overall objectives of this project continue to be related to differentiative pathways of lymphoid cells in humans. Emphasis is on B- and T-cell differentiation and bone marrow differentiation. Differentiation is studied in both normal and malignant cell populations, e.g., in leukemia and lymphoma. The significance of these studies relates primarily to improved understanding of the immune system and its normal function, as well as the abnormal function in immunodeficiencies, autoimmune disorders, and especially, in leukemias and lymphomas. (MI)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA025097-08
Application #
3166690
Study Section
Experimental Immunology Study Section (EI)
Project Start
1979-05-01
Project End
1989-04-30
Budget Start
1986-05-01
Budget End
1987-04-30
Support Year
8
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Woods, W G; Ramsay, N K; Weisdorf, D J et al. (1990) Bone marrow transplantation for acute lymphocytic leukemia utilizing total body irradiation followed by high doses of cytosine arabinoside: lack of superiority over cyclophosphamide-containing conditioning regimens. Bone Marrow Transplant 6:9-16
Griesinger, F; Greenberg, J M; Arthur, D C et al. (1989) Establishment of a leukemic cell line MT-ALL with multilineage differentiation potential. Haematol Blood Transfus 32:214-9
Griesinger, F; Greenberg, J M; Kersey, J H (1989) T cell receptor gamma and delta rearrangements in hematologic malignancies. Relationship to lymphoid differentiation. J Clin Invest 84:506-16
Griesinger, F; Arthur, D C; Brunning, R et al. (1989) Mature T-lineage leukemia with growth factor-induced multilineage differentiation. J Exp Med 169:1101-20
Gonzalez-Sarmiento, R; Greenberg, J M; Kersey, J H (1988) Usage of gamma chain variable regions in human acute lymphoblastic leukemias. Blood 72:2038-41
Miller, W J; Gonzalez-Sarmiento, R; Kersey, J H (1988) Immunoglobulin and T-cell receptor gene rearrangement in blast crisis of chronic myelocytic leukemia. Exp Hematol 16:884-8
Hanson, C A; Frizzera, G; Patton, D F et al. (1988) Clonal rearrangement for immunoglobulin and T-cell receptor genes in systemic Castleman's disease. Association with Epstein-Barr virus. Am J Pathol 131:84-91
Hanson, C A; Kersey, J H (1988) A modified method of DNA extraction from peripheral blood and bone marrow specimens. Am J Hematol 28:176-80
Shapiro, R S; McClain, K; Frizzera, G et al. (1988) Epstein-Barr virus associated B cell lymphoproliferative disorders following bone marrow transplantation. Blood 71:1234-43
Savage, P D; Jones, C; Silver, J et al. (1988) Mapping studies and expression of genes located on human chromosome 11, band q23. Cytogenet Cell Genet 49:289-92

Showing the most recent 10 out of 29 publications