Abstract

The long-term objective of this application is to understand the role of the host immune responses in the progression of mammary neoplasia.
The specific aims focus on two approaches to this objective: (1) characterization of the host responses that accompany the progression of preneoplastic hyperplastic alveolar nodules and relatively benign mammary tumors to frankly neoplastic, metastatic mammary adenocarcinoma. The host response is manipulated in order to define cause-effect relationships. (2) characterization of the host responses that occur within the site of developing neoplasms and within tumor cell variants of distinct behavioral characteristics. The role of the tumor in evoking characteristic T cell and macrophage infiltrates is being elucidated. By focusing on the in situ aspects of host immunity, in the context of neoplastic progression, this application will contribute to rational development of the immunoprevention of cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA027437-09
Application #
3167631
Study Section
Experimental Immunology Study Section (EI)
Project Start
1979-07-01
Project End
1989-06-30
Budget Start
1987-07-01
Budget End
1988-06-30
Support Year
9
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Barbara Ann Karmanos Cancer Institute
Department
Type
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48201

  Publications

Loeffler, D A; KuKuruga, M A; Juneau, P L et al. (1992) Analysis of distribution of tumor- and preneoplasia-infiltrating lymphocytes using simultaneous Hoechst 33342 labeling and immunophenotyping. Cytometry 13:169-74
Loeffler, D A; Juneau, P L; Heppner, G H (1991) Natural killer-cell activity under conditions reflective of tumor micro-environment. Int J Cancer 48:895-9
Wei, W Z; Fulton, A; Winkelhake, J et al. (1989) Correlation of natural killer activity with tumorigenesis of a preneoplastic mouse mammary lesion. Cancer Res 49:2709-15
Paul, L A; Fulton, A M; Heppner, G H (1989) Reactive oxygen-mediated damage to murine mammary tumor cells. Mutat Res 215:223-34
Loeffler, D; Ratner, S (1989) In vivo localization of lymphocytes labelled with low concentrations of Hoechst 33342. J Immunol Methods 119:95-101
Heppner, G H; Chong, Y C; Fulton, A M (1989) Host-mediated induction of tumor heterogeneity. Ann N Y Acad Sci 567:234-42
Ratner, S; Jasti, R K; Heppner, G H (1988) Motility of murine lymphocytes during transit through cell cycle. Analysis by a new in vitro assay. J Immunol 140:583-8
Ratner, S; Heppner, G H (1988) Motility and tumoricidal activity of interleukin-2-stimulated lymphocytes. Cancer Res 48:3374-80
Fulton, A M (1988) The role of eicosanoids in tumor metastasis. Prostaglandins Leukot Essent Fatty Acids 34:229-37
Wei, W Z; Heppner, G H (1988) Tumor infiltrating lymphocytes of spontaneous versus transplanted mouse mammary tumors. Cancer Immunol Immunother 26:257-62

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