Experiments are designed to: (1) establish primary cultures of endothelium derived from capillaries of selected embryonic rudiments, fetal organs, and selected adult sources; (2) produce and identify marker reagents for these endothelial cells to help detect and characterize endothelial cells in general and tissue or organ-defined capillary endothelial subpopulations more specifically; (3) analyze the process of tumor-induced and lymphocyte-induced angiogenesis as this may be reflected differentially or in common for the capillary endothelial cells derived from the various sources; (4) initiate developmental studies aimed at determining the role of endothelial cells in selective cell adhesion; and (5) initiate developmental analysis of the morphogenesis of mouse capillaries during mouse embryogenesis. It is hoped that the outlined research will lead to a better understanding of the developing vascular system and, more specifically, that it will provide new insight into the neovascular process that accompanies the development and metastatic spread of tumors and that is in obligatory association with the inflammatory process. (M)

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA028656-05
Application #
3168242
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1981-05-01
Project End
1989-04-30
Budget Start
1985-05-01
Budget End
1986-04-30
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
Schools of Arts and Sciences
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715