This proposal focuses on the synthesis and biological evaluation of natural and unnatural quassinoids which display solid tumor selectivity. The major thrust of our program is the synthesis of quassinoid analogs for in vitro and in vivo studies in order to define the best candidate to move forward into the clinic. In addition this proposal concentrates on the total synthesis of scytophycin C and tolytoxin. The scytophycins and tolytoxins are solid tumor selective in vitro, however, despite being high priority candidates for in vivo evaluation, no material is available. A major effort will be devoted to probing the structural requirements for solid tumor activity. In part III of this grant application we propose to examine a number of Castela species (plants known to contain quassinoids) in hopes of finding a rich source of glaucarubolone and related quassinoids for our analog program and, more importantly, identifying novel cytotoxic quassinoids as well other natural products which will be solid tumor selective.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA028865-21
Application #
2683418
Study Section
Medicinal Chemistry Study Section (MCHA)
Program Officer
Beisler, John A
Project Start
1980-06-01
Project End
2002-01-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
21
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Montana State University Bozeman
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Bozeman
State
MT
Country
United States
Zip Code
59717
Hunt, K W; Grieco, P A (2000) Baeyer-Villiger oxidation promoted by reaction of peracids with cyclic oxocarbenium ions generated in situ from internal hemiketals. Org Lett 2:1717-9
Grieco, P A; Haddad, J; Pineiro-Nunez, M M et al. (1999) Quassinoids from the twigs and thorns of Castela polyandra. Phytochemistry 50:637-45
Grieco, P A; Haddad, J; Pineiro-Nunez, M M et al. (1999) Non-quassinoid constituents from the twigs and thorns of Castela polyandra. Phytochemistry 51:575-8
Valeriote, F A; Corbett, T H; Grieco, P A et al. (1998) Anticancer activity of glaucarubinone analogues. Oncol Res 10:201-8
Grieco, P A; Vander Roest, J M; Pineiro-Nunez, M M et al. (1995) Polyandrol, a C19 quassinoid from Castela polyandra. Phytochemistry 38:1463-5