Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA030512-05S1
Application #
3169274
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1981-09-01
Project End
1988-12-31
Budget Start
1986-01-01
Budget End
1986-12-31
Support Year
5
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Sri International
Department
Type
DUNS #
City
Menlo Park
State
CA
Country
United States
Zip Code
94025
Howard, W B; Sharma, R P; Willhite, C C et al. (1990) Binding affinities of retinoids to fetal cellular retinoic acid-binding protein (CRABP) in relation to their teratogenic potency in hamsters. Biochem Pharmacol 40:643-8
Norman, A W; Zhou, J Y; Henry, H L et al. (1990) Structure-function studies on analogues of 1 alpha,25-dihydroxyvitamin D3: differential effects on leukemic cell growth, differentiation, and intestinal calcium absorption. Cancer Res 50:6857-64
Dawson, M I; Hobbs, P D (1990) Synthetic retinoid acid analogs: handling and characterization. Methods Enzymol 189:15-43
Sani, B P; Wille Jr, J J; Dawson, M I et al. (1990) Biologically active aromatic retinoids bearing azido photoaffinity-labeling groups and their binding to cellular retinoic acid-binding protein. Chem Biol Interact 75:293-304
Willhite, C C; Dawson, M I (1990) Structure-activity relationships of retinoids in developmental toxicology. IV. Planar Cisoid conformational restriction. Toxicol Appl Pharmacol 103:324-44
Singh, R K; Sani, B P; Dawson, M I et al. (1989) Affinity purification of cellular retinoic acid-binding protein on 14-carboxy-13-cis-retinamide-sepharose 4B. Biochem J 262:917-22
Dawson, M I; Hobbs, P D; Derdzinski, K A et al. (1989) Effect of structural modifications in the C7-C11 region of the retinoid skeleton on biological activity in a series of aromatic retinoids. J Med Chem 32:1504-17
Howard, W B; Willhite, C C; Dawson, M I et al. (1988) Structure-activity relationships of retinoids in developmental toxicology. III. Contribution of the vitamin A beta-cyclogeranylidene ring. Toxicol Appl Pharmacol 95:122-38
Dawson, M I; Chao, W R; Helmes, C T (1987) Inhibition by retinoids of anthralin-induced mouse epidermal ornithine decarboxylase activity and anthralin-promoted skin tumor formation. Cancer Res 47:6210-5
Mehta, R G; Schiff, L J; Moore, S J et al. (1986) Cellular retinoic acid-binding protein and its relationship to the biological activity of four synthetic retinoids in hamster tracheal organ culture. In Vitro Cell Dev Biol 22:164-8

Showing the most recent 10 out of 11 publications