Advances in pediatric oncology have provided for a increasingly positive prognosis for childhood leukemia. Initial concern for survival is now being augmented by concern about the neuropsychological sequelae of treatment.
The aim of the proposed project is to evaluate the longitudinal effects of prophylactic CNS Therapy, intensive CNS Therapy, and no CNS Therapy (control group for the cancer experience per se) on the neuropsychological status of pediatric oncology patients. A test battery developed by a neuropsychologist expressly for the evaluation, will be administered at diagnosis and at yearly intervals. The neuropsychology battery includes the following measures: intelligence, motor and constructional skills, spatialtactile skills, language ability, memory and learning, and academic achievement. Additional information from 2 CT scans, at the beginning and end of treatment, a parents' behavior checklist, and a teacher's school report will supplement the primary data base. The performance of both Spanish and English speaking patients will be evaluated. Data analysis will test the hypothesis that consistent progressive, patterns of disturbances in the child's neuropsychological functioning are associated with the CNS treatment under investigation. Separate data analysis procedures will provide an estimate of how, when and to what degree a particular child is effected, and the degree to which a particular CNS Therapy may place the child at developmental risk with respect to established norms. This information will not only provide the oncologist with pertinent information, but will enable the patient to be counseled for appropriate academic placement.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA033097-03
Application #
3171034
Study Section
Behavioral Medicine Study Section (BEM)
Project Start
1983-02-01
Project End
1986-01-31
Budget Start
1985-02-01
Budget End
1986-01-31
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Type
Hospitals
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
Papazoglou, Aimilia; King, Tricia Z; Morris, Robin D et al. (2009) Parent report of attention problems predicts later adaptive functioning in children with brain tumors. Child Neuropsychol 15:40-52
Papazoglou, Aimilia; King, Tricia Z; Morris, Robin D et al. (2008) Attention mediates radiation's impact on daily living skills in children treated for brain tumors. Pediatr Blood Cancer 50:1253-7
Papazoglou, Aimilia; King, Tricia Z; Morris, Robin D et al. (2008) Cognitive predictors of adaptive functioning vary according to pediatric brain tumor location. Dev Neuropsychol 33:505-20
Micklewright, Jackie L; King, Tricia Z; Morris, Robin D et al. (2008) Quantifying pediatric neuro-oncology risk factors: development of the neurological predictor scale. J Child Neurol 23:455-8
Copeland, D R; deMoor, C; Moore 3rd, B D et al. (1999) Neurocognitive development of children after a cerebellar tumor in infancy: A longitudinal study. J Clin Oncol 17:3476-86
Ater, J L; van Eys, J; Woo, S Y et al. (1997) MOPP chemotherapy without irradiation as primary postsurgical therapy for brain tumors in infants and young children. J Neurooncol 32:243-52
Copeland, D R; Moore 3rd, B D; Francis, D J et al. (1996) Neuropsychologic effects of chemotherapy on children with cancer: a longitudinal study. J Clin Oncol 14:2826-35
Ater, J L; Moore 3rd, B D; Francis, D J et al. (1996) Correlation of medical and neurosurgical events with neuropsychological status in children at diagnosis of astrocytoma: utilization of a neurological severity score. J Child Neurol 11:462-9
Carlson-Green, B; Morris, R D; Krawiecki, N (1995) Family and illness predictors of outcome in pediatric brain tumors. J Pediatr Psychol 20:769-84
Francis, D J; Copeland, D R; Moore 3rd, B D (1994) Neuropsychological changes in children with cancer: the treatment of missing data in longitudinal studies. Neuropsychol Rev 4:199-222

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