The goals of this project are to identify and monitor the effects of cancer and its treatment on the neuropsychological development of children. A large cohort of children with leukemia and solid tumors have been followed through three years of treatment to assess the effects of central nervous system (CNS) treatment on children ' with leukemia. However, patients were followed for a relatively brief period, and brain tumor patients were excluded from the investigation. In contrast to children with tumors outside the CNS and whose disease and treatment are usually less 1 intensive, children with brain tumors show a high incidence of neuropsychological impairment severe enough to interfere with their attainment of long-term educational and occupational goals.
The aims of this prospective study are to 1) extend our knowledge of longitudinal change in participants in the current prospective study to periods of 6-8 years post-diagnosis; 2) examine changes in neuropsychological performance of children with brain tumors across a three-year period beginning at diagnosis; 3) compare changes in performance of children with brain tumors with those of other cancer patients; and 4) identify characteristics of patients. diseases, and treatments that will contribute to the interpretation of neuropsychological findings. This study will extend the time line of the current study as well as generate a cross-validation sample of brain tumor and other types of cancer patients from whom comparable data will be obtained. To achieve the first objective, 100 surviving participants in the currently funded study will be followed for an additional three years to assess change over long- term post-therapy follow-up. To achieve Objectives 2 and 3, studies of 120 brain tumor patients and 120 other cancer patients will be conducted using a repeated measures design. Patterns of decline and growth will be assessed using a hierarchical linear modeling approach. All groups will be included in the analyses of Objective 4. To meet sample requirements for Objectives 2 and 3 and to enhance generalizability of findings, The University of Texas H. D. Anderson Cancer Center and Georgia State University/Emory have agreed to collaborate. Achievement of these aims will enhance our ability to identify risk factors associated with specific processing deficits among pediatric cancer patients and assess their implications for school achievements.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA033097-10
Application #
3171039
Study Section
Behavioral Medicine Study Section (BEM)
Project Start
1983-02-01
Project End
1994-04-30
Budget Start
1992-05-01
Budget End
1993-04-30
Support Year
10
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Type
Other Domestic Higher Education
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
Papazoglou, Aimilia; King, Tricia Z; Morris, Robin D et al. (2009) Parent report of attention problems predicts later adaptive functioning in children with brain tumors. Child Neuropsychol 15:40-52
Micklewright, Jackie L; King, Tricia Z; Morris, Robin D et al. (2008) Quantifying pediatric neuro-oncology risk factors: development of the neurological predictor scale. J Child Neurol 23:455-8
Papazoglou, Aimilia; King, Tricia Z; Morris, Robin D et al. (2008) Attention mediates radiation's impact on daily living skills in children treated for brain tumors. Pediatr Blood Cancer 50:1253-7
Papazoglou, Aimilia; King, Tricia Z; Morris, Robin D et al. (2008) Cognitive predictors of adaptive functioning vary according to pediatric brain tumor location. Dev Neuropsychol 33:505-20
Copeland, D R; deMoor, C; Moore 3rd, B D et al. (1999) Neurocognitive development of children after a cerebellar tumor in infancy: A longitudinal study. J Clin Oncol 17:3476-86
Ater, J L; van Eys, J; Woo, S Y et al. (1997) MOPP chemotherapy without irradiation as primary postsurgical therapy for brain tumors in infants and young children. J Neurooncol 32:243-52
Copeland, D R; Moore 3rd, B D; Francis, D J et al. (1996) Neuropsychologic effects of chemotherapy on children with cancer: a longitudinal study. J Clin Oncol 14:2826-35
Ater, J L; Moore 3rd, B D; Francis, D J et al. (1996) Correlation of medical and neurosurgical events with neuropsychological status in children at diagnosis of astrocytoma: utilization of a neurological severity score. J Child Neurol 11:462-9
Carlson-Green, B; Morris, R D; Krawiecki, N (1995) Family and illness predictors of outcome in pediatric brain tumors. J Pediatr Psychol 20:769-84
Francis, D J; Copeland, D R; Moore 3rd, B D (1994) Neuropsychological changes in children with cancer: the treatment of missing data in longitudinal studies. Neuropsychol Rev 4:199-222

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