Abstract

This investigation is designed to achieve a greater understanding the chemistry of technetium, and to use this knowledge in the rational design of new radiopharmaceuticals incorporating the radionuclide 99mTc. Beginning with already characterized compounds in well-defined oxidation states complexes will be prepared, isolated and studied using methods which have been successfully applied to the coordination chemistry of other transition metals.
The aim of the synthetic program is to give a profile of the oxidation state, stereochemistry, nature of the bonding and the relative ligand affinities of technetium compounds. As the systematics of the element's behavior emerge, this information will be applied to the designing and synthesizing of materials which show potential as radiodiagnostic agents. These will then be evaluated in appropriate animal models.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA034970-09
Application #
3172755
Study Section
Metallobiochemistry Study Section (BMT)
Project Start
1977-02-01
Project End
1987-03-31
Budget Start
1985-04-01
Budget End
1987-03-31
Support Year
9
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code

  Publications

Zaheer, A; Lenkinski, R E; Mahmood, A et al. (2001) In vivo near-infrared fluorescence imaging of osteoblastic activity. Nat Biotechnol 19:1148-54
Packard, A B; Barbarics, E; Kronauge, J F et al. (1997) Comparison of uptake of 99mTc-alkylisonitriles in the rat 9L gliosarcoma tumor model. Nucl Med Biol 24:21-5
Herman, L W; Sharma, V; Kronauge, J F et al. (1995) Novel hexakis(areneisonitrile)technetium(I) complexes as radioligands targeted to the multidrug resistance P-glycoprotein. J Med Chem 38:2955-63
Verdera, S; Lopez, J J; Tagle, R et al. (1994) Radiopharmacological evaluation in dogs of a new renal function agent. J Nucl Biol Med 38:79-85
Piwnica-Worms, D P; Kronauge, J F; LeFurgey, A et al. (1994) Mitochondrial localization and characterization of 99Tc-SESTAMIBI in heart cells by electron probe X-ray microanalysis and 99Tc-NMR spectroscopy. Magn Reson Imaging 12:641-52
Barbarics, E; Kronauge, J F; Costello, C E et al. (1994) In vivo metabolism of the technetium isonitrile complex [Tc(2-ethoxy-2-methyl-1-isocyanopropane)6]+. Nucl Med Biol 21:583-91
Packard, A B; Kronauge, J F; Limpa-Amara, N et al. (1993) Tumor uptake of 99mTc-MIBI and 201Tl by a 9L gliosarcoma brain tumor model in rats. Nucl Med Biol 20:773-6
Verdera, S; Leon, A; Kronauge, J F et al. (1993) Radiopharmacological studies of 99mTc-CPI: experience with isolated rat atrial tissue. Nucl Med Biol 20:127-32
Carvalho, P A; Chiu, M L; Kronauge, J F et al. (1992) Subcellular distribution and analysis of technetium-99m-MIBI in isolated perfused rat hearts. J Nucl Med 33:1516-22
Delmon-Moingeon, L I; Mahmood, A; Davison, A et al. (1991) Strategies for labeling monoclonal antibodies and antibody-like molecules with technetium-99m. J Nucl Biol Med 35:47-59

Showing the most recent 10 out of 16 publications