Abstract

The PI proposes to continue his studies on the molecular pathogenesis of AIDS-associated lymphomas. The PI has recently discovered that approximately 40% of the diffuse large cell lymphomas (DLCL) associated with AIDS contain rearrangements in the 5'noncoding region of the BCL-6 gene. In this project, he will further characterize the structural alterations of BCL-6 in DLCL, elucidate the biological consequences of BCL-6 alterations on tumor pathogenesis and Epstein-Barr virus gene expression, and attempt to identify additional genetic alterations associated with lymphomas in AIDS.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA037295-17
Application #
6164111
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Program Officer
Read-Connole, Elizabeth Lee
Project Start
1984-04-01
Project End
2002-02-28
Budget Start
2000-03-10
Budget End
2001-02-28
Support Year
17
Fiscal Year
2000
Total Cost
$348,181
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Zhang, Jiyuan; Dominguez-Sola, David; Hussein, Shafinaz et al. (2015) Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis. Nat Med 21:1190-8
Pasqualucci, Laura; Khiabanian, Hossein; Fangazio, Marco et al. (2014) Genetics of follicular lymphoma transformation. Cell Rep 6:130-40
Ying, Carol Y; Dominguez-Sola, David; Fabi, Melissa et al. (2013) MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma. Nat Immunol 14:1084-92
Dominguez-Sola, David; Victora, Gabriel D; Ying, Carol Y et al. (2012) The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry. Nat Immunol 13:1083-91
Challa-Malladi, Madhavi; Lieu, Yen K; Califano, Olivia et al. (2011) Combined genetic inactivation of ?2-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma. Cancer Cell 20:728-40
Trifonov, Vladimir; Pasqualucci, Laura; Dalla-Favera, Riccardo et al. (2011) Fractal-like distributions over the rational numbers in high-throughput biological and clinical data. Sci Rep 1:191
Fabbri, Giulia; Rasi, Silvia; Rossi, Davide et al. (2011) Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. J Exp Med 208:1389-401
Pasqualucci, Laura; Trifonov, Vladimir; Fabbri, Giulia et al. (2011) Analysis of the coding genome of diffuse large B-cell lymphoma. Nat Genet 43:830-7
Pasqualucci, Laura; Dominguez-Sola, David; Chiarenza, Annalisa et al. (2011) Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature 471:189-95
Mandelbaum, Jonathan; Bhagat, Govind; Tang, Hongyan et al. (2010) BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma. Cancer Cell 18:568-79

Showing the most recent 10 out of 64 publications