Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA040823-08
Application #
3181123
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1985-09-01
Project End
1993-08-31
Budget Start
1992-04-30
Budget End
1992-08-31
Support Year
8
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Wayne State University
Department
Type
Organized Research Units
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Quan, T; Reiners Jr, J J; Bell, A O et al. (1994) Cytotoxicity and genotoxicity of (+/-)-benzo[a]pyrene-trans-7,8-dihydrodiol in CYP1A1-expressing human fibroblasts quantitatively correlate with CYP1A1 expression level. Carcinogenesis 15:1827-32
Scholler, A; Hong, N J; Bischer, P et al. (1994) Short and long term effects of cytoskeleton-disrupting drugs on cytochrome P450 Cyp1a-1 induction in murine hepatoma 1c1c7 cells: suppression by the microtubule inhibitor nocodazole. Mol Pharmacol 45:944-54
Reiners Jr, J J; Scholler, A; Bischer, P et al. (1993) Suppression of cytochrome P450 Cyp1a-1 induction in murine hepatoma 1c1c7 cells by 12-O-tetradecanoylphorbol-13-acetate and inhibitors of protein kinase C. Arch Biochem Biophys 301:449-54
Reiners Jr, J J; Cantu, A R; Scholler, A (1992) Phorbol ester-mediated suppression of cytochrome P450 Cyp1a-1 induction in murine skin: involvement of protein kinase C. Biochem Biophys Res Commun 186:970-6
Reiners Jr, J J; Cantu, A R; Thai, G et al. (1992) Differential expression of basal and hydrocarbon-induced cytochrome P-450 monooxygenase and quinone reductase activities in subpopulations of murine epidermal cells differing in their stages of differentiation. Drug Metab Dispos 20:360-6
Reiners Jr, J J; Pavone, A; Cantu, A R et al. (1992) Differential expression of cytochrome P-450 in proliferating and quiescent cultures of murine lung epithelial cells. Biochem Biophys Res Commun 183:193-8
Reiners Jr, J J; Cantu, A R; Pavone, A (1991) Distribution of constitutive and polycyclic aromatic hydrocarbon-induced cytochrome P-450 activities in murine epidermal cells that differ in their stages of differentiation. Prog Clin Biol Res 369:123-35
Reiners Jr, J J; Kodari, E; Cappel, R E et al. (1991) Assessment of the antioxidant/prooxidant status of murine skin following topical treatment with 12-O-tetradecanoylphorbol-13-acetate and throughout the ontogeny of skin cancer. Part II: Quantitation of glutathione and glutathione disulfide. Carcinogenesis 12:2345-52
Reiners Jr, J J; Thai, G; Rupp, T et al. (1991) Assessment of the antioxidant/prooxidant status of murine skin following topical treatment with 12-O-tetradecanoylphorbol-13-acetate and throughout the ontogeny of skin cancer. Part I: Quantitation of superoxide dismutase, catalase, glutathione peroxidase Carcinogenesis 12:2337-43
Reiners Jr, J J; Rupp, T; Conti, C J (1991) Modulation of xanthine dehydrogenase and oxidase activities during the hormonal induction of vaginal epithelial differentiation in ovariectomized mice. Differentiation 47:69-75

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