The goals of this proposal are to determine 1) the degree of nonlinearity of human tissues, 2) how this information can be exploited to obtain reliable ultrasound images, and finally 3) what type of information nonlinearity can provide about the nature and disease of tissues. We have recently described a technique to measure the nonlinear parameter B/A by measuring the phase of sound transmitted through tissues. For better precision and reliability we will computerize the technique and use it to detemrine B/A for a large number of excised human tissues. Each sample will also be analyzed for fat-water composition and a correlation, if any, will be established between B/A and tissue composition. Also, ultrasound computer-assisted tomography will be utilized to obtain images of acoustic nonlinearity by measuring the perssure amplitude of the difference fequency generated from the propagation of two coincident primary waves of different frequencies. The results of this study will enable us to evaluate the potential role of nonlinear acoustics in biomedicine.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA041324-02
Application #
3181714
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1986-03-01
Project End
1989-02-28
Budget Start
1987-03-01
Budget End
1988-02-29
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
Kim, D; Greenleaf, J F; Sehgal, C M (1990) Ultrasonic imaging of the nonlinear parameter B/A: simulation studies to evaluate phase and frequency modulation methods. Ultrasound Med Biol 16:175-81
Errabolu, R L; Sehgal, C M; Bahn, R C et al. (1988) Measurement of ultrasonic nonlinear parameter in excised fat tissues. Ultrasound Med Biol 14:137-46
Errabolu, R L; Sehgal, C M; Greenleaf, J F (1987) Dependence of ultrasonic nonlinear parameter B/A on fat. Ultrason Imaging 9:180-94
Sehgal, C M; Brown, G M; Bahn, R C et al. (1986) Measurement and use of acoustic nonlinearity and sound speed to estimate composition of excised livers. Ultrasound Med Biol 12:865-74