The aim of this research is to develop synthetic methodologoy which will permit the development of a short and efficient general synthesis of antitumor taxanes. Several of these have been shown to be potent antitumor substances and one (taxol) is currently in clinical trials. Successful completion of this project will provide an abundant supply of taxol, as well as providing synthetic analogs which will be available for testing as antitumor agents. This project is also designed to provide new synthetic methodology which will be of general utility in the field of chemical synthesis.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA042031-02
Application #
3182770
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1985-06-01
Project End
1991-06-30
Budget Start
1986-07-01
Budget End
1987-06-30
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Florida State University
Department
Type
Schools of Arts and Sciences
DUNS #
020520466
City
Tallahassee
State
FL
Country
United States
Zip Code
32306