The development of synthetic methodology leading to the total synthesis of taxol is proposed. Taxol is one of the most potent new antitumor drug prospects, and it is currently in Phase III Clinical Trials against ovarian cancer and Phase II Clinical Trials against breast cancer. Other Clinical Trials are planned. The supply of taxol is currently severely limited, and development of synthesis of the drug will potentially solve this problem. In addition, this work will also provide the knowledge to permit the synthesis of a large number of taxol mimics, some of which are very likely to have better antitumor activity than taxol itself. These studies will also lead to a better understanding of taxol's mechanism of action, which, in turn, will lead to the development of new, superior taxol related drugs.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA042031-08
Application #
3182777
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1985-06-01
Project End
1995-07-31
Budget Start
1992-08-01
Budget End
1993-07-31
Support Year
8
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Florida State University
Department
Type
Schools of Arts and Sciences
DUNS #
020520466
City
Tallahassee
State
FL
Country
United States
Zip Code
32306