Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA042229-08
Application #
2090631
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1988-04-01
Project End
1997-03-31
Budget Start
1995-04-01
Budget End
1997-03-31
Support Year
8
Fiscal Year
1995
Total Cost
Indirect Cost
Name
New York University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012
Roghani, Monireh; Moscatelli, David (2007) Prostate cells express two isoforms of fibroblast growth factor receptor 1 with different affinities for fibroblast growth factor-2. Prostate 67:115-24
Richard, C; Roghani, M; Moscatelli, D (2000) Fibroblast growth factor (FGF)-2 mediates cell attachment through interactions with two FGF receptor-1 isoforms and extracellular matrix or cell-associated heparan sulfate proteoglycans. Biochem Biophys Res Commun 276:399-405
Liuzzo, J P; Moscatelli, D (1996) Human leukemia cell lines bind basic fibroblast growth factor (FGF) on FGF receptors and heparan sulfates: downmodulation of FGF receptors by phorbol ester. Blood 87:245-55
Roghani, M; Mohammadi, M; Schlessinger, J et al. (1996) Induction of urokinase-type plasminogen activator by fibroblast growth factor (FGF)-2 is dependent on expression of FGF receptors and does not require activation of phospholipase Cgamma1. J Biol Chem 271:31154-9
Chow, R L; Roux, G D; Roghani, M et al. (1995) FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens. Development 121:4383-93
Richard, C; Liuzzo, J P; Moscatelli, D (1995) Fibroblast growth factor-2 can mediate cell attachment by linking receptors and heparan sulfate proteoglycans on neighboring cells. J Biol Chem 270:24188-96
Roghani, M; Mansukhani, A; Dell'Era, P et al. (1994) Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding. J Biol Chem 269:3976-84
Rifkin, D B; Moscatelli, D; Roghani, M et al. (1994) Studies on FGF-2: nuclear localization and function of high molecular weight forms and receptor binding in the absence of heparin. Mol Reprod Dev 39:102-4;discussion 104-5
Moscatelli, D (1994) Autocrine downregulation of fibroblast growth factor receptors in F9 teratocarcinoma cells. J Cell Physiol 160:555-62
Huang, Y Q; Li, J J; Moscatelli, D et al. (1993) Expression of int-2 oncogene in Kaposi's sarcoma lesions. J Clin Invest 91:1191-7

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