The central goal is the development of new MRI techniques, or new combinations of established techniques, for distinguishing tumors from normal tissue or inflammation. This is an important clinical diagnostic problem when diagnosing or staging cancer. While conventional MRI can often detect tumors, it is often difficult to distinguish them from imflammation or edema. A secondary goal is relating MR images to tumor vascular patterns and tumor oxygenation. Tumor oxygenation is an important factor in determining the response to radiation therapy. These goals will be approached by combining the information obtained from images of protons, fluorine, and sodium. The proton images will be used for their anatomical detail. The fluorine images will be of fluorinated blood substitutes and will dilineate vascular anatomy and measure the vascular oxygen tension. The sodium images will be of endogenous sodium which in biological systems shows two components of T2 decay. Chemical shift reagents will be used to identify the intra and extracellular components. We will determine whether the short T2 component can be used to distinguish tumors from edema. The work will be done in a variety of animal tumors of known vascularity and radiosensitivity. If successful, the techniques can be transferred to human imaging and should lead to improved tumor diagnosis.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA044580-05
Application #
3187244
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1987-05-01
Project End
1993-04-30
Budget Start
1991-05-01
Budget End
1993-04-30
Support Year
5
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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Meyer, K L; Joseph, P M; Mukherji, B et al. (1993) Measurement of vascular volume in experimental rat tumors by 19F magnetic resonance imaging. Invest Radiol 28:710-9
Meyer, K L; Carvlin, M J; Mukherji, B et al. (1992) Fluorinated blood substitute retention in the rat measured by fluorine-19 magnetic resonance imaging. Invest Radiol 27:620-7
Summers, R M; Joseph, P M; Kundel, H L (1991) Sodium nuclear magnetic resonance imaging of neuroblastoma in the nude mouse. Invest Radiol 26:233-41
Mukherji, B; Sloviter, H A (1991) A stable perfluorochemical blood substitute. Transfusion 31:324-6
Bogdan, A R; Joseph, P M (1990) RASEE: a rapid spin-echo pulse sequence. Magn Reson Imaging 8:13-9
Fishman, J E; Joseph, P M; Carvlin, M J et al. (1989) In vivo measurements of vascular oxygen tension in tumors using MRI of a fluorinated blood substitute. Invest Radiol 24:65-71
Summers, R M; Joseph, P M; Renshaw, P F et al. (1988) Dextran-magnetite: a contrast agent for sodium-23 MRI. Magn Reson Med 8:427-39