Acute lymphoblastic leukemia (ALL) is the most common form of malignancy in children under 15 years of age, with an annual incidence rate of 37.8 per million in the United States. Childhood ALL has been demonstrated to include a heterogenous group of leukemias which markedly differ clinically and/or biologically. The Childrens Cancer Study Group (CCSG), a cooperative clinical trials study group, proposes to study the role of risk factors for childhood ALL within biologically defined subgroups. This study will assess whether biologically or clinically distinct subgroups of ALL are also etiologically distinct. The proposed study will include a total of 2000 newly diagnosed cases of childhood ALL ascertained during a four year period. Cases will be compared to a series of age-, sex- and race-matched regional population controls selected using a random digit dialing methodology. Parents of cases and controls will be interviewed by telephone. The matched pairs design will be used to quantify, within biologically distinct subgroups of ALL, the risk associated with selected environmental and genetic risk factors, as well as their possible interaction. These patient subgroups will be defined based on FAB morphology, state-of-the-art assessment of immunophenotypes and cytogenetics which will be available from CCSG for the case population. A study of this size will have sufficient power to allow identification of risk factors of even the less common ALL subtypes, in addition to providing sufficient power to allow a comprehensive assessment of specific risk factors and their interaction for childhood ALL as a whole.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA048051-05S1
Application #
3191968
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1988-09-01
Project End
1994-06-30
Budget Start
1992-07-01
Budget End
1994-06-30
Support Year
5
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Rudant, Jérémie; Lightfoot, Tracy; Urayama, Kevin Y et al. (2015) Childhood acute lymphoblastic leukemia and indicators of early immune stimulation: a Childhood Leukemia International Consortium study. Am J Epidemiol 181:549-62
Bailey, Helen D; Infante-Rivard, Claire; Metayer, Catherine et al. (2015) Home pesticide exposures and risk of childhood leukemia: Findings from the childhood leukemia international consortium. Int J Cancer 137:2644-63
Bailey, Helen D; Metayer, Catherine; Milne, Elizabeth et al. (2015) Home paint exposures and risk of childhood acute lymphoblastic leukemia: findings from the Childhood Leukemia International Consortium. Cancer Causes Control 26:1257-70
Bailey, Helen D; Fritschi, Lin; Infante-Rivard, Claire et al. (2014) Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: findings from the childhood leukemia international consortium. Int J Cancer 135:2157-72
Bailey, Helen D; Fritschi, Lin; Metayer, Catherine et al. (2014) Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium. Cancer Causes Control 25:1351-67
Roman, Eve; Lightfoot, Tracy; Smith, Alexandra G et al. (2013) Childhood acute lymphoblastic leukaemia and birthweight: insights from a pooled analysis of case-control data from Germany, the United Kingdom and the United States. Eur J Cancer 49:1437-47
Milne, Elizabeth; Greenop, Kathryn R; Metayer, Catherine et al. (2013) Fetal growth and childhood acute lymphoblastic leukemia: findings from the childhood leukemia international consortium. Int J Cancer 133:2968-79
Bunin, Greta R; Spector, Logan G; Olshan, Andrew F et al. (2007) Secular trends in response rates for controls selected by random digit dialing in childhood cancer studies: a report from the Children's Oncology Group. Am J Epidemiol 166:109-16
Shu, Xiao Ou; Perentesis, John P; Wen, Wanqing et al. (2004) Parental exposure to medications and hydrocarbons and ras mutations in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group. Cancer Epidemiol Biomarkers Prev 13:1230-5
Shu, Xiao Ou; Potter, John D; Linet, Martha S et al. (2002) Diagnostic X-rays and ultrasound exposure and risk of childhood acute lymphoblastic leukemia by immunophenotype. Cancer Epidemiol Biomarkers Prev 11:177-85

Showing the most recent 10 out of 20 publications