Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA048085-03
Application #
3192063
Study Section
Experimental Immunology Study Section (EI)
Project Start
1988-07-15
Project End
1993-06-30
Budget Start
1990-01-01
Budget End
1990-06-30
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Arizona
Department
Type
Schools of Medicine
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85722
Harris, D T; Jaso-Friedmann, L; Evans, D L (1994) Target-cell sensitivity to natural killer-cell lysis is determined by the expression of a novel antigen in conjunction with major histocompatibility complex class-I molecules. Scand J Immunol 39:73-8
Jaso-Friedmann, L; Leary 3rd, J H; Evans, D L (1994) Pathways of signaling in nonspecific cytotoxic cells: effects of protein kinase and phosphatase inhibitors and evidence for membrane tyrosine phosphorylation. Cell Immunol 153:142-53
Jaso-Friedmann, L; Leary 3rd, J H; Evans, D L (1993) Nonspecific cytotoxic cells in fish: antigenic cross-reactivity of a function associated molecule with the intermediate filament vimentin. Cell Immunol 148:208-17
Jaso-Friedmann, L; Leary 3rd, J H; Evans, D L (1993) Role of function-associated molecules in target cell lysis: analysis of rat adherent lymphokine-activated killer cells. Nat Immun 12:316-25
Evans, D L; Jaso-Friedmann, L (1993) Natural killer (NK) cells in domestic animals: phenotype, target cell specificity and cytokine regulation. Vet Res Commun 17:429-47
Harris, D T; Jaso-Friedmann, L; Evans, D L (1993) A novel target cell antigen involved in the NK-like lytic activity of antigen-specific cytotoxic T lymphocytes. Immunol Lett 38:11-8
Jaso-Friedmann, L; Leary 3rd, J H; St John, A L et al. (1992) Detection of function-associated molecules on rat NK cells and their role in target cell lysis. Cell Immunol 141:131-47
Evans, D L; Harris, D T; Jaso-Friedmann, L (1992) Function associated molecules on nonspecific cytotoxic cells: role in calcium signaling, redirected lysis, and modulation of cytotoxicity. Dev Comp Immunol 16:383-94
Evans, D L; Harris, D T; Leary 3rd, J et al. (1992) A function-associated molecule on rat natural killer cells identified by anti-idiotypic monoclonal antibodies. Cell Immunol 141:293-305
Evans, D L; Harris, D T; Jaso-Friedmann, L (1990) Effects of phorbol esters and calcium ionophore on nonspecific cytotoxic cells. Dev Comp Immunol 14:223-30

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