Gene Specific Inhibition of Cytochrome P-450 Isoforms

Iversen, Patrick L.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 5R01CA049135-03
• Application #: 3193101
• Study Section: Chemical Pathology Study Section (CPA)
• Project Start: 1989-02-01
• Project End: 1993-01-31
• Budget Start: 1991-02-01
• Budget End: 1993-01-31
• Support Year: 3
• Fiscal Year: 1991

Institution

• Name: University of Nebraska Medical Center
• Type: Schools of Medicine
• City: Omaha
• State: NE
• Country: United States
• Zip Code: 68198

Publications

Desjardins, J; Mata, J; Brown, T et al. (1995) Cholesteryl-conjugated phosphorothioate oligodeoxynucleotides modulate CYP2B1 expression in vivo. J Drug Target 2:477-85

Tracewell, W; Desjardins, J; Iversen, P (1995) In vivo modulation of the rat cytochrome P450 1A1 by double-stranded phosphorothioate oligodeoxynucleotides. Toxicol Appl Pharmacol 135:179-84

Ebadi, M; Iversen, P L (1994) Metallothionein in carcinogenesis and cancer chemotherapy. Gen Pharmacol 25:1297-310

Iversen, P L; Ebadi, M (1992) Antisense oligonucleotide-mediated inhibition of metallothionein protein synthesis in neuroblastoma IMR 32 and Chang liver cells in culture. Biol Signals 1:57-64