Purpose of study. We have identified the protein-coding region of the estrogen first detected this structural variant in samples. We found that whereas tissue samples containing only the common form of the mRNA showed a positive correlation between the amount of estrogen receptor (ER) mRNA and ER protein, the tissue population carrying the variant form showed no such quantitative correlation. This finding suggested that the variant form of the gene may be defective. Moreover, while the concentration of ER mRNA varied substantially among tissues carrying the common form of the gene, tissues containing the variant mRNA contained lower overall ER mRNA concentrations. We therefore wish to obtain more structural and functional information about the variant ER gene and the population of individuals carrying it. Specifically, we propose to answer the following questions: A. What is the DNA sequence of the variant ER gene? Does it give rise to a functional mutation? B. If the variant gene is functionally mutated, is the homozygous state a developmentally lethal one? C. Are there identifiable functional correlates of heterozygosity, such as late onset of puberty, early onset of menopause, amenorrhea, polycystic ovaries, or other gynecologic problems? D. Do women carrying a variant gene who develop breast cancer have relatively less responsiveness to Tamoxifen therapy and/or abnormally short survival times?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA049506-01A1
Application #
3193644
Study Section
Reproductive Endocrinology Study Section (REN)
Project Start
1989-09-30
Project End
1992-07-31
Budget Start
1989-09-30
Budget End
1990-07-31
Support Year
1
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10029
Lehrer, Steven; Rheinstein, Peter H (2018) Alzheimer's Disease and Intranasal Fluticasone Propionate in the FDA MedWatch Adverse Events Database. J Alzheimers Dis Rep 2:111-115
Lehrer, Steven; Rheinstein, Peter H; Rosenzweig, Kenneth E (2018) Increased expression of von Willebrand factor gene is associated with poorer survival in primary lower grade glioma. Glioma 1:132-135
Lehrer, Steven; Rheinstein, Peter H (2016) A derangement of the brain wound healing process may cause some cases of Alzheimer's disease. Discov Med 22:43-6
Lehrer, Steven; Green, Sheryl; Rosenzweig, Kenneth E (2016) Reduced Ovarian Cancer Incidence in Women Exposed to Low Dose Ionizing Background Radiation or Radiation to the Ovaries after Treatment for Breast Cancer or Rectosigmoid Cancer. Asian Pac J Cancer Prev 17:2979-82
Lehrer, Steven (2015) Continuation of gradual weight gain necessary for the onset of puberty may be responsible for obesity later in life. Discov Med 20:191-6
Lehrer, Steven; Rosenzweig, Kenneth E (2014) Cold Climate Is a Risk Factor for Thyroid Cancer. Clin Thyroidol 26:273-276
Lehrer, Steven (2010) Anopheles mosquito transmission of brain tumor. Med Hypotheses 74:167-8