Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA050195-04
Application #
3194538
Study Section
Special Emphasis Panel (SRC (50))
Project Start
1989-05-01
Project End
1994-04-30
Budget Start
1992-05-01
Budget End
1993-04-30
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Shay, J W; Tomlinson, G; Piatyszek, M A et al. (1995) Spontaneous in vitro immortalization of breast epithelial cells from a patient with Li-Fraumeni syndrome. Mol Cell Biol 15:425-32
Zhang, W; Guo, X Y; Hu, G Y et al. (1994) A temperature-sensitive mutant of human p53. EMBO J 13:2535-44
Kim, N W; Piatyszek, M A; Prowse, K R et al. (1994) Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011-5
Tam, S W; Theodoras, A M; Shay, J W et al. (1994) Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression. Oncogene 9:2663-74
Tam, S W; Shay, J W; Pagano, M (1994) Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4. Cancer Res 54:5816-20
Zhang, W; Shay, J W; Deisseroth, A (1993) Inactive p53 mutants may enhance the transcriptional activity of wild-type p53. Cancer Res 53:4772-5
Zhang, W; Funk, W D; Wright, W E et al. (1993) Novel DNA binding of p53 mutants and their role in transcriptional activation. Oncogene 8:2555-9
Van der Haegen, B A; Shay, J W (1993) Immortalization of human mammary epithelial cells by SV40 large T-antigen involves a two step mechanism. In Vitro Cell Dev Biol 29A:180-2
Shay, J W; Van Der Haegen, B A; Ying, Y et al. (1993) The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen. Exp Cell Res 209:45-52
Shay, J W; Wright, W E; Brasiskyte, D et al. (1993) E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts. Oncogene 8:1407-13

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