Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA050270-06
Application #
2093689
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1991-01-01
Project End
1997-12-31
Budget Start
1996-03-10
Budget End
1996-12-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Internal Medicine/Medicine
Type
Other Domestic Higher Education
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
Ling, Yi-He; Liebes, Leonard; Jiang, Jian-Dong et al. (2003) Mechanisms of proteasome inhibitor PS-341-induced G(2)-M-phase arrest and apoptosis in human non-small cell lung cancer cell lines. Clin Cancer Res 9:1145-54
Ling, Yi-He; Jiang, Jian-Dong; Holland, James F et al. (2002) Arsenic trioxide produces polymerization of microtubules and mitotic arrest before apoptosis in human tumor cell lines. Mol Pharmacol 62:529-38
Ling, Yi-He; Liebes, Leonard; Ng, Bruce et al. (2002) PS-341, a novel proteasome inhibitor, induces Bcl-2 phosphorylation and cleavage in association with G2-M phase arrest and apoptosis. Mol Cancer Ther 1:841-9
Ling, Y; Zhong, Y; Perez-Soler, R (2001) Disruption of cell adhesion and caspase-mediated proteolysis of beta- and gamma-catenins and APC protein in paclitaxel-induced apoptosis. Mol Pharmacol 59:593-603
Faderl, S; Estrov, Z; Kantarjian, H M et al. (2001) WP744, a novel anthracycline with enhanced proapoptotic and antileukemic activity. Anticancer Res 21:3777-84
Ling, Y H; Donato, N J; Perez-Soler, R (2001) Sensitivity to topoisomerase I inhibitors and cisplatin is associated with epidermal growth factor receptor expression in human cervical squamous carcinoma ME180 sublines. Cancer Chemother Pharmacol 47:473-80
Perez-Soler, R; Kemp, B; Wu, Q P et al. (2000) Response and determinants of sensitivity to paclitaxel in human non-small cell lung cancer tumors heterotransplanted in nude mice. Clin Cancer Res 6:4932-8
Qu, X; Trent, J O; Fokt, I et al. (2000) Allosteric, chiral-selective drug binding to DNA. Proc Natl Acad Sci U S A 97:12032-7
Marbeuf-Gueye, C; Priebe, W; Garnier-Suillerot, A (2000) Multidrug resistance protein functionality: no effect of intracellular or extracellular pH changes. Biochem Pharmacol 60:1485-9
Ling, Y H; Zou, Y; Perez-Soler, R (2000) Induction of senescence-like phenotype and loss of paclitaxel sensitivity after wild-type p53 gene transfection of p53-null human non-small cell lung cancer H358 cells. Anticancer Res 20:693-702

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