Mechanisms of Igf-II Action During Hepatocarcinogenesis

Rogler, Charles E.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 5R01CA056076-05
• Application #: 2097082
• Study Section: Pathology B Study Section (PTHB)
• Project Start: 1992-07-01
• Project End: 1997-02-28
• Budget Start: 1996-03-01
• Budget End: 1997-02-28
• Support Year: 5
• Fiscal Year: 1996

Institution

• Name: Albert Einstein College of Medicine
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 009095365
• City: Bronx
• State: NY
• Country: United States
• Zip Code: 10461

Publications

Harris, T M; Rogler, L E; Rogler, C E (1998) Reactivation of the maternally imprinted IGF2 allele in TGFalpha induced hepatocellular carcinomas in mice. Oncogene 16:203-9

Yang, D; Faris, R; Hixson, D et al. (1996) Insulin-like growth factor II blocks apoptosis of N-myc2-expressing woodchuck liver epithelial cells. J Virol 70:6260-8

Rossetti, L; Barzilai, N; Chen, W et al. (1996) Hepatic overexpression of insulin-like growth factor-II in adulthood increases basal and insulin-stimulated glucose disposal in conscious mice. J Biol Chem 271:203-8

Rogler, C E; Yang, D; Rossetti, L et al. (1994) Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice. J Biol Chem 269:13779-84