The ets oncongene superfamily codes for a family of transcriptional factors of which some are involved in leukemias, lymphomas and sarcomas. Previously, we have identified and characterized a new member of this oncogene family elk-1. Recently, we have shown that elk-1 is a transcriptional activator which regulates c-fos oncogene activity. We plan to study the mechanism of activation of fos by elk-1 proteins, identify the natural targets and study the role in cell growth, differentiation, signal transduction and cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA057322-01A4
Application #
2098055
Study Section
Pathology B Study Section (PTHB)
Project Start
1995-06-01
Project End
2000-05-31
Budget Start
1995-06-01
Budget End
1996-05-31
Support Year
1
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Fortson, Wendell S; Kayarthodi, Shubhalaxmi; Fujimura, Yasuo et al. (2011) Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. Int J Oncol 39:111-9
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