Abstract

The ets oncongene superfamily codes for a family of transcriptional factors of which some are involved in leukemias, lymphomas and sarcomas. Previously, we have identified and characterized a new member of this oncogene family elk-1. Recently, we have shown that elk-1 is a transcriptional activator which regulates c-fos oncogene activity. We plan to study the mechanism of activation of fos by elk-1 proteins, identify the natural targets and study the role in cell growth, differentiation, signal transduction and cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA057322-01A4
Application #
2098055
Study Section
Pathology B Study Section (PTHB)
Project Start
1995-06-01
Project End
2000-05-31
Budget Start
1995-06-01
Budget End
1996-05-31
Support Year
1
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Thomas Jefferson University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107

  Publications

Fortson, Wendell S; Kayarthodi, Shubhalaxmi; Fujimura, Yasuo et al. (2011) Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. Int J Oncol 39:111-9
Maniccia, Anna W; Lewis, Catherine; Begum, Nurjahan et al. (2009) Mitochondrial localization, ELK-1 transcriptional regulation and growth inhibitory functions of BRCA1, BRCA1a, and BRCA1b proteins. J Cell Physiol 219:634-41
Ramakrishnan, Ramugounder; Fujimura, Yasuo; Zou, Jian Ping et al. (2004) Role of protein-protein interactions in the antiapoptotic function of EWS-Fli-1. Oncogene 23:7087-94
Chai, Y; Chipitsyna, G; Cui, J et al. (2001) c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells. Oncogene 20:1357-67
Fujimura, Y; Siddique, H; Lee, L et al. (2001) EWS-ATF-1 chimeric protein in soft tissue clear cell sarcoma associates with CREB-binding protein and interferes with p53-mediated trans-activation function. Oncogene 20:6653-9
Chai, Y L; Cui, J; Shao, N et al. (1999) The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter. Oncogene 18:263-8
Zou, J P; Hirose, Y; Siddique, H et al. (1999) Structure and expression of variant BRCA2a lacking the transactivation domain. Oncol Rep 6:437-40
Dhulipala, P D; Lee, L; Rao, V N et al. (1998) Fli-1b is generated by usage of differential splicing and alternative promoter. Oncogene 17:1149-57
Siddique, H; Zou, J P; Rao, V N et al. (1998) The BRCA2 is a histone acetyltransferase. Oncogene 16:2283-5
Shao, N; Chai, Y; Cui, J Q et al. (1998) Induction of apoptosis by Elk-1 and deltaElk-1 proteins. Oncogene 17:527-32

Showing the most recent 10 out of 16 publications