Metabolism of Catechol Estrogens

Monks, Terrence J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 5R01CA058036-04
• Application #: 2098755
• Study Section: Special Emphasis Panel (SRC (68))
• Project Start: 1992-08-01
• Project End: 1997-07-31
• Budget Start: 1995-08-01
• Budget End: 1997-07-31
• Support Year: 4
• Fiscal Year: 1995

Institution

• Name: University of Texas Austin
• Department: Pharmacology
• Type: Schools of Pharmacy
• City: Austin
• State: TX
• Country: United States
• Zip Code: 78712

Publications

Monks, T J; Lau, S S (1998) The pharmacology and toxicology of polyphenolic-glutathione conjugates. Annu Rev Pharmacol Toxicol 38:229-55

Butterworth, M; Lau, S S; Monks, T J (1998) 2-Hydroxy-4-glutathion-S-yl-17beta-estradiol and 2-hydroxy-1-glutathion-S-yl-17beta-estradiol produce oxidative stress and renal toxicity in an animal model of 17beta-estradiol-mediated nephrocarcinogenicity. Carcinogenesis 19:133-9

Butterworth, M; Lau, S S; Monks, T J (1997) Formation of catechol estrogen glutathione conjugates and gamma-glutamyl transpeptidase-dependent nephrotoxicity of 17beta-estradiol in the golden Syrian hamster. Carcinogenesis 18:561-7

Butterworth, M; Lau, S S; Monks, T J (1996) 17 beta-estradiol metabolism by hamster hepatic microsomes: comparison of catechol estrogen O-methylation with catechol estrogen oxidation and glutathione conjugation. Chem Res Toxicol 9:793-9

Butterworth, M; Lau, S S; Monks, T J (1996) 17 beta-Estradiol metabolism by hamster hepatic microsomes. Implications for the catechol-O-methyl transferase-mediated detoxication of catechol estrogens. Drug Metab Dispos 24:588-94