This grant will address several aspects of the potential affects of bioactive agents on leukemia cells in vivo. Leukemia cells will be obtained before and after administration of these agents and the effects of these agents on the distribution of cell cycle times amongst the leukemia cells within individual patients will be explored. The effects of these agents on the expression of the protooncogenes fms, myb, IL1beta and myc will be studied as well. Initially, we will study the effects of retinoic acid/interferon and rhGM-CSF. The studies will be extended to other agents once these initial studies are completed. Parallel evaluation of the bioactive agents in vitro will be conducted so that predictive in vitro assays can be developed.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA060086-04
Application #
2100704
Study Section
Special Emphasis Panel (SRC)
Project Start
1992-08-01
Project End
1997-05-31
Budget Start
1994-08-01
Budget End
1995-05-31
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Rush University Medical Center
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60612
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