Abstract

This grant will address several aspects of the potential affects of bioactive agents on leukemia cells in vivo. Leukemia cells will be obtained before and after administration of these agents and the effects of these agents on the distribution of cell cycle times amongst the leukemia cells within individual patients will be explored. The effects of these agents on the expression of the protooncogenes fms, myb, IL1beta and myc will be studied as well. Initially, we will study the effects of retinoic acid/interferon and rhGM-CSF. The studies will be extended to other agents once these initial studies are completed. Parallel evaluation of the bioactive agents in vitro will be conducted so that predictive in vitro assays can be developed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA060086-04
Application #
2100704
Study Section
Special Emphasis Panel (SRC)
Project Start
1992-08-01
Project End
1997-05-31
Budget Start
1994-08-01
Budget End
1995-05-31
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Rush University Medical Center
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60612

  Publications

Li, B; Yang, J; Andrews, C et al. (2000) Telomerase activity in preleukemia and acute myelogenous leukemia. Leuk Lymphoma 36:579-87
Preisler, H D; Gao, X Z; Ming, T et al. (1999) Marrow cytokine transcripts and the secondary hematologic disorders. Leuk Lymphoma 35:297-302
Mundle, S; Venugopal, P; Shetty, V et al. (1999) The relative extent and propensity of CD34+ vs. CD34- cells to undergo apoptosis in myelodysplastic marrows. Int J Hematol 69:152-9
Gao, X Z; Bi, S; Copra, H et al. (1998) Cytokine gene activity in AML cells in vivo in patients. Leuk Res 22:429-38
Preisler, H D; Bi, S; Venugopal, P et al. (1997) Cytokines, molecular biological abnormalities, and acute myelogenous leukemia. Leuk Res 21:299-312
Handa, H; Hegde, U P; Kotelnikov, V M et al. (1997) Bcl-2 and c-myc expression, cell cycle kinetics and apoptosis during the progression of chronic myelogenous leukemia from diagnosis to blastic phase. Leuk Res 21:479-89
Braun, D P; Preisler, H D (1997) Cytolytic activity of peripheral blood blast cells from patients with acute myeloid leukemia. Leuk Lymphoma 27:459-67
Raza, A; Alvi, S; Borok, R Z et al. (1997) Excessive proliferation matched by excessive apoptosis in myelodysplastic syndromes: the cause-effect relationship. Leuk Lymphoma 27:111-8
Raza, A; Alvi, S; Broady-Robinson, L et al. (1997) Cell cycle kinetic studies in 68 patients with myelodysplastic syndromes following intravenous iodo- and/or bromodeoxyuridine. Exp Hematol 25:530-5
Handa, H; Hegde, U P; Kotelnikov, V M et al. (1997) The effects of 13-cis retinoic acid and interferon-alpha in chronic myelogenous leukemia cells in vivo in patients. Leuk Res 21:1087-96

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