Mechanisms of DNA Degradation by Free Radicals

Crich, David

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 5R01CA060500-03
• Application #: 2101262
• Study Section: Bio-Organic and Natural Products Chemistry Study Section (BNP)
• Project Start: 1994-07-01
• Project End: 1997-06-30
• Budget Start: 1996-07-01
• Budget End: 1997-06-30
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: University of Illinois at Chicago
• Department: Chemistry
• Type: Schools of Arts and Sciences
• DUNS #: 121911077
• City: Chicago
• State: IL
• Country: United States
• Zip Code: 60612

Publications

Crich, David; Grant, Daniel (2008) Intramolecular Homolytic Aromatic Substitution of Alkyl 2-Benzimidazolyl Sulfones as a Means of Entry into Alkyl Radicals for Organic Synthesis. Tetrahedron Lett 49:2999-3003

Crich, D; Huang, W (2001) Dynamics of alkene radical cation/phosphate anion pair formation from nucleotide C4' radicals. The DNA/RNA paradox revisited. J Am Chem Soc 123:9239-45

Newcomb, M; Miranda, N; Sannigrahi, M et al. (2001) Direct measurement of enol ether radical cation reaction kinetics. J Am Chem Soc 123:6445-6

Bales, B C; Horner, J H; Huang, X et al. (2001) Product studies and laser flash photolysis on alkyl radicals containing two different beta-leaving groups are consonant with the formation of an olefin cation radical. J Am Chem Soc 123:3623-9

Whitted, P O; Horner, J H; Newcomb, M et al. (1999) Heterolytic cleavage of a beta-phosphatoxyalkyl radical resulting in phosphate migration or radical cation formation as a function of solvent polarity. Org Lett 1:153-6