Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA063260-05S1
Application #
2752160
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Program Officer
Freeman, Colette S
Project Start
1994-06-01
Project End
2002-01-31
Budget Start
1998-04-01
Budget End
1999-01-31
Support Year
5
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Whitehead Institute for Biomedical Research
Department
Type
DUNS #
076580745
City
Cambridge
State
MA
Country
United States
Zip Code
02142
Xiao, Zhan; Latek, Robert; Lodish, Harvey F (2003) An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity. Oncogene 22:1057-69
Schiemann, William P; Blobe, Gerard C; Kalume, Dario E et al. (2002) Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades. J Biol Chem 277:27367-77
Blobe, G C; Schiemann, W P; Pepin, M C et al. (2001) Functional roles for the cytoplasmic domain of the type III transforming growth factor beta receptor in regulating transforming growth factor beta signaling. J Biol Chem 276:24627-37
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Rodriguez, C; Huang, L J; Son, J K et al. (2001) Functional cloning of the proto-oncogene brain factor-1 (BF-1) as a Smad-binding antagonist of transforming growth factor-beta signaling. J Biol Chem 276:30224-30
Blobe, G C; Liu, X; Fang, S J et al. (2001) A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC. J Biol Chem 276:39608-17
Liu, X; Sun, Y; Weinberg, R A et al. (2001) Ski/Sno and TGF-beta signaling. Cytokine Growth Factor Rev 12:1-8
Xiao, Z; Watson, N; Rodriguez, C et al. (2001) Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals. J Biol Chem 276:39404-10
Xiao, Z; Liu, X; Henis, Y I et al. (2000) A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation. Proc Natl Acad Sci U S A 97:7853-8
Blobe, G C; Schiemann, W P; Lodish, H F (2000) Role of transforming growth factor beta in human disease. N Engl J Med 342:1350-8

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