Screening-type computed tomography (CT) of the chest, directed to the detection of small solitary pulmonary nodules (SSPN), is developing to such an extent that both its cost and radiation dose are approaching those of the traditional chest radiograph (CXR), while its sensitivity in the detection of SSPN is much higher. This development dramatically brightens the prospects for cost-effective screening for early, curable lung cancer in high-risk people. Complete evaluation of the implications of this development is a matter of quantifying l) how often screening-type CT of the chest leads to detection of SSPN in asymptomatic persons at high risk for lung cancer. 2) how often such a SSPN - or one representing an incidental finding -- is malignant, and 3) how often such a malignant SSPN is curable. Our team of investigators is committed to address all three of these questions. To address the first question, some 1000 persons at high risk for lung cancer will be screened for SSPN in the context of periodic health examinations, using both CXR and screening-type CT. The primary aim in this component is to determine the prevalence of CT-detectable SSPN as a joint function of various risk-relevant characteristics of the person. The prevalence of malignancy among the detected cases of SSPN will also be addressed among the screening-detected cases of SSPN. For complete development of the diagnostic function, a larger total series of CT- detected SSPNs will be derived from a multi-institutional SSPN """"""""registry"""""""". A subsequent study of curability based on the multi- institutional registry, is not a part of this research application, but the protocol for this is presented as part of our overall plan.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA063393-01A1
Application #
2105210
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1995-04-07
Project End
1998-03-31
Budget Start
1995-04-07
Budget End
1996-03-31
Support Year
1
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065
Yip, Rowena; Henschke, Claudia I; Yankelevitz, David F et al. (2015) The impact of the regimen of screening on lung cancer cure: a comparison of I-ELCAP and NLST. Eur J Cancer Prev 24:201-8
Henschke, Claudia I; Yip, Rowena; Boffetta, Paolo et al. (2015) CT screening for lung cancer: Importance of emphysema for never smokers and smokers. Lung Cancer 88:42-7
Yankelevitz, David F; Yip, Rowena; Smith, James P et al. (2015) CT Screening for Lung Cancer: Nonsolid Nodules in Baseline and Annual Repeat Rounds. Radiology 277:555-64
Xu, Dong Ming; Yip, Rowena; Smith, James P et al. (2014) Retrospective review of lung cancers diagnosed in annual rounds of CT screening. AJR Am J Roentgenol 203:965-72
Altorki, Nasser K; Yip, Rowena; Hanaoka, Takaomi et al. (2014) Sublobar resection is equivalent to lobectomy for clinical stage 1A lung cancer in solid nodules. J Thorac Cardiovasc Surg 147:754-62; Discussion 762-4
Austin, John H M; Yip, Rowena; D'Souza, Belinda M et al. (2012) Small-cell carcinoma of the lung detected by CT screening: stage distribution and curability. Lung Cancer 76:339-43
Henschke, Claudia I; Yankelevitz, David F; Yip, Rowena et al. (2012) Lung cancers diagnosed at annual CT screening: volume doubling times. Radiology 263:578-83
Zulueta, Javier J; Wisnivesky, Juan P; Henschke, Claudia I et al. (2012) Emphysema scores predict death from COPD and lung cancer. Chest 141:1216-1223
Wildstein, Kimberly A; Faustini, Yolanda; Yip, Rowena et al. (2011) Longitudinal predictors of adherence to annual follow-up in a lung cancer screening programme. J Med Screen 18:154-9
Reeves, Anthony P; Chan, Antoni B; Yankelevitz, David F et al. (2006) On measuring the change in size of pulmonary nodules. IEEE Trans Med Imaging 25:435-50

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