The long-term goal of this project is to identify tumor susceptibility genes involved in lung cancer development. There are six specific aims: 1) to generate pedigrees for lung cancer susceptible families; 2) to obtain normal and tumor tissue samples from as many family members as possible; 3) to genotype DNA from family members with appropriate markers; 4) to perform linkage analyses to identify potential loci involved in lung cancer susceptibility; 5) to genotype the entire genome with equally spaced microsatellite markers and perform linkage analysis with these data; and, 6.) if putative loci are localized, to refine the linkage map of the candidate loci.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA063700-05
Application #
6512903
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Program Officer
Seminara, Daniela
Project Start
1997-05-05
Project End
2005-02-28
Budget Start
2002-03-01
Budget End
2005-02-28
Support Year
5
Fiscal Year
2002
Total Cost
$169,709
Indirect Cost
Name
St. Mary's Hospital & Regional Medical Center
Department
Type
DUNS #
City
Grand Junction
State
CO
Country
United States
Zip Code
81506
Liu, Pengyuan; Yang, Ping; Wu, Xifeng et al. (2010) A second genetic variant on chromosome 15q24-25.1 associates with lung cancer. Cancer Res 70:3128-35
You, Ming; Wang, Daolong; Liu, Pengyuan et al. (2009) Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene. Clin Cancer Res 15:2666-74
Liu, Pengyuan; Vikis, Haris G; Wang, Daolong et al. (2008) Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. J Natl Cancer Inst 100:1326-30