The long-term goal of this project is to identify tumor susceptibility genes involved in lung cancer development. There are six specific aims: 1) to generate pedigrees for lung cancer susceptible families; 2) to obtain normal and tumor tissue samples from as many family members as possible; 3) to genotype DNA from family members with appropriate markers; 4) to perform linkage analyses to identify potential loci involved in lung cancer susceptibility; 5) to genotype the entire genome with equally spaced microsatellite markers and perform linkage analysis with these data; and, 6.) if putative loci are localized, to refine the linkage map of the candidate loci.
| Liu, Pengyuan; Yang, Ping; Wu, Xifeng et al. (2010) A second genetic variant on chromosome 15q24-25.1 associates with lung cancer. Cancer Res 70:3128-35 |
| You, Ming; Wang, Daolong; Liu, Pengyuan et al. (2009) Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene. Clin Cancer Res 15:2666-74 |
| Liu, Pengyuan; Vikis, Haris G; Wang, Daolong et al. (2008) Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. J Natl Cancer Inst 100:1326-30 |
