Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA064489-03S1
Application #
2765611
Study Section
Radiation Study Section (RAD)
Program Officer
Mahoney, Francis J
Project Start
1996-05-03
Project End
2000-02-29
Budget Start
1998-03-01
Budget End
1999-02-28
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Stanford University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Green, S L; Freiberg, R A; Giaccia, A J (2001) p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest. Mol Cell Biol 21:1196-206
Koumenis, C; Alarcon, R; Hammond, E et al. (2001) Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. Mol Cell Biol 21:1297-310
Maecker, H L; Koumenis, C; Giaccia, A J (2000) p53 promotes selection for Fas-mediated apoptotic resistance. Cancer Res 60:4638-44
Zundel, W; Swiersz, L M; Giaccia, A (2000) Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide. Mol Cell Biol 20:1507-14
Denko, N; Schindler, C; Koong, A et al. (2000) Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment. Clin Cancer Res 6:480-7
Alarcon, R; Koumenis, C; Geyer, R K et al. (1999) Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation. Cancer Res 59:6046-51
Wouters, B G; Denko, N C; Giaccia, A J et al. (1999) A p53 and apoptotic independent role for p21waf1 in tumour response to radiation therapy. Oncogene 18:6540-5
Soengas, M S; Alarcon, R M; Yoshida, H et al. (1999) Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science 284:156-9
Brown, J M; Giaccia, A J (1998) The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res 58:1408-16
Giaccia, A J; Kastan, M B (1998) The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev 12:2973-83

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