Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA067405-02
Application #
2111088
Study Section
Special Emphasis Panel (ZRG3-ET-2 (01))
Project Start
1995-06-01
Project End
1999-03-31
Budget Start
1996-04-05
Budget End
1997-03-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Upstate Medical University
Department
Pathology
Type
Schools of Medicine
DUNS #
058889106
City
Syracuse
State
NY
Country
United States
Zip Code
13210
Ewton, Daina Z; Hu, Jing; Vilenchik, Maria et al. (2011) Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells. Mol Cancer Ther 10:2104-14
Hu, Jing; Friedman, Eileen (2010) Depleting Mirk Kinase Increases Cisplatin Toxicity in Ovarian Cancer Cells. Genes Cancer 1:803-811
Jin, Kideok; Ewton, Daina Z; Park, Sunju et al. (2009) Mirk regulates the exit of colon cancer cells from quiescence. J Biol Chem 284:22916-25
Deng, Xiaobing; Ewton, Daina Z; Friedman, Eileen (2009) Mirk/Dyrk1B maintains the viability of quiescent pancreatic cancer cells by reducing levels of reactive oxygen species. Cancer Res 69:3317-24
Jin, Kideok; Park, Sunju; Ewton, Daina Z et al. (2007) The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer. Cancer Res 67:7247-55
Mercer, Stephen E; Ewton, Daina Z; Shah, Sejal et al. (2006) Mirk/Dyrk1b mediates cell survival in rhabdomyosarcomas. Cancer Res 66:5143-50
Deng, Xiaobing; Ewton, Daina Z; Li, Sheena et al. (2006) The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma. Cancer Res 66:4149-58
Mercer, Stephen E; Friedman, Eileen (2006) Mirk/Dyrk1B: a multifunctional dual-specificity kinase involved in growth arrest, differentiation, and cell survival. Cell Biochem Biophys 45:303-15
Mercer, Stephen E; Ewton, Daina Z; Deng, Xiaobing et al. (2005) Mirk/Dyrk1B mediates survival during the differentiation of C2C12 myoblasts. J Biol Chem 280:25788-801
Deng, Xiaobing; Ewton, Daina Z; Mercer, Stephen E et al. (2005) Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation. J Biol Chem 280:4894-905

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