Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA067941-05A1
Application #
6094636
Study Section
Metabolic Pathology Study Section (MEP)
Program Officer
Seminara, Daniela
Project Start
1996-03-15
Project End
2005-03-31
Budget Start
2000-05-19
Budget End
2001-03-31
Support Year
5
Fiscal Year
2000
Total Cost
$541,978
Indirect Cost
Name
Ohio State University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210
Le, Dung T; Durham, Jennifer N; Smith, Kellie N et al. (2017) Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science 357:409-413
Haraldsdottir, Sigurdis; Hampel, Heather; Wu, Christina et al. (2016) Patients with colorectal cancer associated with Lynch syndrome and MLH1 promoter hypermethylation have similar prognoses. Genet Med 18:863-8
Goodenberger, McKinsey L; Thomas, Brittany C; Riegert-Johnson, Douglas et al. (2016) PMS2 monoallelic mutation carriers: the known unknown. Genet Med 18:13-9
Le, Dung T; Uram, Jennifer N; Wang, Hao et al. (2015) PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N Engl J Med 372:2509-20
Pasche, Boris; Pennison, Michael J; Jimenez, Hugo et al. (2014) TGFBR1 and cancer susceptibility. Trans Am Clin Climatol Assoc 125:300-12
Haraldsdottir, Sigurdis; Hampel, Heather; Tomsic, Jerneja et al. (2014) Colon and endometrial cancers with mismatch repair deficiency can arise from somatic, rather than germline, mutations. Gastroenterology 147:1308-1316.e1
Tomsic, J; Senter, L; Liyanarachchi, S et al. (2013) Recurrent and founder mutations in the PMS2 gene. Clin Genet 83:238-43
Hampel, Heather; de la Chapelle, Albert (2013) How do we approach the goal of identifying everybody with Lynch syndrome? Fam Cancer 12:313-7
Moreira, Leticia; Balaguer, Francesc; Lindor, Noralane et al. (2012) Identification of Lynch syndrome among patients with colorectal cancer. JAMA 308:1555-65
Mercado, Rowena C; Hampel, Heather; Kastrinos, Fay et al. (2012) Performance of PREMM(1,2,6), MMRpredict, and MMRpro in detecting Lynch syndrome among endometrial cancer cases. Genet Med 14:670-80

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