Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA070406-01
Application #
2114299
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1996-04-01
Project End
2000-01-31
Budget Start
1996-04-01
Budget End
1997-01-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Fiorani, Paola; Reid, Robert J D; Schepis, Antonino et al. (2004) The deubiquitinating enzyme Doa4p protects cells from DNA topoisomerase I poisons. J Biol Chem 279:21271-81
Bjornsti, Mary Ann (2002) Cancer therapeutics in yeast. Cancer Cell 2:267-73
Woo, Michael H; Vance, John R; Marcos, Ana R Otero et al. (2002) Active site mutations in DNA topoisomerase I distinguish the cytotoxic activities of camptothecin and the indolocarbazole, rebeccamycin. J Biol Chem 277:3813-22
Woo, M H; Vance, J R; Bjornsti, M A (2001) Studying DNA topoisomerase I-targeted drugs in the yeast. Saccharomyces cerevisiae. Methods Mol Biol 95:303-13
Fiorani, P; Bjornsti, M A (2000) Mechanisms of DNA topoisomerase I-induced cell killing in the yeast Saccharomyces cerevisiae. Ann N Y Acad Sci 922:65-75
Kang, J J; Schaber, M D; Srinivasula, S M et al. (1999) Cascades of mammalian caspase activation in the yeast Saccharomyces cerevisiae. J Biol Chem 274:3189-98
Bjornsti, M A; Fertala, J (1999) Overexpression and purification of DNA topoisomerase I from yeast. Methods Mol Biol 94:179-86
Fiorani, P; Amatruda, J F; Silvestri, A et al. (1999) Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity. Mol Pharmacol 56:1105-15
Bjornsti, M A; Osheroff, N (1999) Introduction to DNA topoisomerases. Methods Mol Biol 94:1-8
Reid, R J; Fiorani, P; Sugawara, M et al. (1999) CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage. Proc Natl Acad Sci U S A 96:11440-5

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